Most Read Articles
Stephen Padilla, 01 Feb 2019
More children are expected to be diagnosed with hypertension based on the new criteria for high blood pressure (HBP) in young people, according to a new study. In addition, the strength of association of HBP with body mass index (BMI) and other medical and behavioural factors has not changed, supporting the validity of the new definition.
29 Nov 2018
Pulmonary hypertension (PH) is associated with underlying risk factors in children with congenital hyperinsulinism (HI) treated with diazoxide, reports a study. Other adverse events, however, do not show any identifiable risk profile.
18 Jan 2019
Azithromycin treatment in children with recurrent asthma-like symptoms acutely disrupts gut microbiota composition, a recent study has found.
14 Jan 2019
The application of mupirocin to multiple body sites of infants appears to be safe and effective for eradicating Staphylococcus aureus carriage in the neonatal intensive care unit setting, a study has found. However, recolonization occurs after 2–3 weeks in a number of infants who remain hospitalized.

Oxygen exposure, intermittent hypoxemia in preemies tied to childhood symptomatic wheezing

09 Feb 2019

Extremely premature neonates with cumulative inspired oxygen exposure and frequent intermittent hypoxaemia (IH) events during the first 3 days of age are at increased risk of symptomatic childhood wheezing requiring prescription asthma medications, reports a study.

The single-centre retrospective study included 137 premature infants born at <28 weeks gestational age. Researchers explored possible associations of cumulative oxygen, cumulative mean airway pressure, IH and oxygen saturation (SpO2) with the primary outcome of prescription asthma medication use at 2-year follow-up.

Reported use of prescription asthma medication at 2 years was 46 percent. Children with vs without asthma prescription were more likely to be born to mothers with asthma and have bronchopulmonary dysplasia (BPD), defined as need for supplemental oxygen or positive pressure at 36 weeks postmenstrual age. Other patient characteristics were similar.

Factors associated with an increased likelihood of receiving childhood asthma medications included higher cumulative oxygen and mean airway pressure exposure, more frequent IH events, and lower mean oxygen saturation (SpO2) during the first 3 days of age. However, in adjusted Poisson regression models, only elevated cumulative oxygen exposure, increased daily IH and lower mean SpO2 were associated with childhood asthma medication use.

The findings show that increased oxygen and frequent IH events during just the first 3 days of age may help pinpoint extremely premature infants at risk of filling childhood asthma medication prescriptions, researchers said.

Early recognition of premature infants prone to developing symptomatic wheezing may help improve patient care by allowing targeted surveillance and intervention, family education and preventative measures against environmental triggers, they added.

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Most Read Articles
Stephen Padilla, 01 Feb 2019
More children are expected to be diagnosed with hypertension based on the new criteria for high blood pressure (HBP) in young people, according to a new study. In addition, the strength of association of HBP with body mass index (BMI) and other medical and behavioural factors has not changed, supporting the validity of the new definition.
29 Nov 2018
Pulmonary hypertension (PH) is associated with underlying risk factors in children with congenital hyperinsulinism (HI) treated with diazoxide, reports a study. Other adverse events, however, do not show any identifiable risk profile.
18 Jan 2019
Azithromycin treatment in children with recurrent asthma-like symptoms acutely disrupts gut microbiota composition, a recent study has found.
14 Jan 2019
The application of mupirocin to multiple body sites of infants appears to be safe and effective for eradicating Staphylococcus aureus carriage in the neonatal intensive care unit setting, a study has found. However, recolonization occurs after 2–3 weeks in a number of infants who remain hospitalized.