Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Roshini Claire Anthony, 12 Feb 2020

Children with inflammatory bowel disease (IBD) do not appear to have an elevated risk of lymphoma following treatment with anti-tumour necrosis factor (TNF) agents, according to a study presented at the recent Crohn’s and Colitis Congress 2020.

Jairia Dela Cruz, 3 days ago
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
Pearl Toh, 14 Feb 2020
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).

Overweight, obesity tied to higher liver biochemical markers in youths

09 Feb 2020

Children and adolescents who are overweight or obese tend to have elevated biochemical markers of liver damage, a study has shown. Moreover, variations in paediatric normal values of liver enzymes exist across age and sex groups.

Participants were recruited from two cohorts of Danish youths: 1,858 from a population-based cohort and 2,155 with overweight or obesity, aged 6–18 years. The authors calculated age- and sex-specific percentile curves for the following markers: fasting plasma concentrations of alanine transaminase (ALT), aspartate transaminase (AST), lactate dehydrogenase (LDH), gamma-glutamiltransferase (GGT), bilirubin and alkaline phosphatase (ALP) in both cohorts. Proton magnetic resonance spectroscopy was used in 458 participants to assess their hepatic fat content.

Concentrations of ALT, AST, LDH and ALP decreased with age in both girls and boys. On the other hand, GGT and bilirubin concentrations increased slightly with age in boys and were similar across age groups in girls. Overweight and obesity were associated with higher concentration of ALT in all age groups. Concentrations of ALT, and to some extent GGT, increased with age in overweight or obese boys.

In addition, the optimal ALT cut-points for diagnosis hepatic steatosis (liver fat content >5 percent) was 24.5 U/L for girls (sensitivity, 55.6 percent; specificity, 84.0 percent) and 34.5 U/L for boys (sensitivity, 83.7 percent; specificity, 68.2 percent).

“These findings emphasize the need for prevention and treatment of overweight and obesity in children and adolescents,” the authors said.

“Elevated plasma concentrations of liver enzymes are routinely used as markers of liver injury in adults and children,” they added.

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Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Roshini Claire Anthony, 12 Feb 2020

Children with inflammatory bowel disease (IBD) do not appear to have an elevated risk of lymphoma following treatment with anti-tumour necrosis factor (TNF) agents, according to a study presented at the recent Crohn’s and Colitis Congress 2020.

Jairia Dela Cruz, 3 days ago
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
Pearl Toh, 14 Feb 2020
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).