Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

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The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Overhydration may lead to sarcopaenia in peritoneal dialysis patients

24 Apr 2020
Intellis system offers transformative dialysis care option

Peritoneal dialysis (PD) patients with inadequate fluid removal or high water intake are more likely to have reduced muscle mass indices and develop sarcopaenia, a study has shown.

The investigators included all incident PD patients surviving ≥1 year after PD initiation in this analysis, which sought to examine the effects of volume status on body composition in this population. In total, 366 incident PD patients met the eligibility criteria and were categorized into three tertiles according to the time-averaged-oedema index (TA-EI).

Bioimpedance analysis was conducted to measure the following body composition parameters: EI, fat mass index (FMI, kg/m2) and appendicular muscle mass index (AMMI, kg/m2). Both dFMI and dAMMI were defined as delta values for the corresponding variable.

The cutoff value for sarcopaenia was defined as previously reported. Participants with AMMI below the cutoff values were considered as having sarcopaenia.

Of the participants, 126 were included in the low, 100 in the middle and 140 in the high tertile. A high volume status or overhydration correlated with high solute clearance, albumin loss and glucose absorption through the peritoneal membrane, resulting in high dialysate glucose.

Volume status, on the other hand, was inversely associated with increases in AMMI and did not correlate with changes in FMI. Sarcopaenia as a categorical variable showed a positive association with high volume status. Subgroup analyses revealed that TA-EI had the greatest negative correlation coefficients for dAMMI.

“Inadequate fluid removal or high water intake leads to overhydration, which results in malnutrition,” the investigators noted.

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Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.