Ovarian lipid metabolism modulates circulating premenopausal lipids
Ovarian lipid metabolism and other previously unappreciated factors appear to contribute to the lipid profile in premenopausal women, a recent study has found.
A significant association existed between oestradiol and increased levels of high-density lipoprotein (HDL) cholesterol throughout the menstrual cycle and in the follicular phase. Ovarian effects correlated with reduced lipid levels, particularly during the luteal phase. Furthermore, oral contraceptive (OC) was associated with an increased total cholesterol to HDL cholesterol ratio and triglycerides.
Researchers conducted an experimental crossover with repeated measures in academic hospitals involving eight healthy, regularly menstruating women to assess how oestradiol, progesterone and ovarian lipid metabolism contributed to the premenopausal lipid profile, and to evaluate the acute effects of a common hormonal OC on circulating lipids,
Participants underwent periodic serum sampling during a normal menstrual cycle; a standard 21-day, monophasic combined hormonal OC cycle (30 µg of ethinyl oestradiol and 150 µg of levonorgestrel/day); menopause simulated by leuprolide acetate (22.5-mg depot); and an artificial menstrual cycle achieved via transdermal oestradiol (50 to 300 µg/day) and vaginal micronized progesterone (100 to 300 mg/day).
Evaluation of total cholesterol, HDL cholesterol, low-density lipoprotein cholesterol, triglycerides and the total cholesterol-to-HDL cholesterol ratio were the primary outcomes. All specimens except from the OC cycle were analysed to estimate the effect of oestradiol, progesterone and ovarian lipid metabolism. Researchers conducted subgroup analysis on the follicular and luteal phases. In a separate analysis, they assessed the effect of the OC in relation to the normal menstrual cycle.
The findings demonstrated the association of premenopausal circulating lipid profile with hormonal profile and ovarian lipid metabolism, according to researchers.