Most Read Articles
Tristan Manalac, 4 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
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Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 6 days ago
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Outcomes for splanchnic vein thrombosis poor in patients with liver cirrhosis

05 Sep 2018

The risk of long-term and recurrent thrombotic events is elevated in cirrhotic patients with splanchnic vein thrombosis (SVT), a recent study has found.

A total of 604 consecutive SVT patients were enrolled in the study, of whom 149 (median age 59 years; 71.1 percent) were cirrhotic. Incidence rates of major bleeding, all-cause mortality and thrombotic events over a 2-year period were collected. Kaplan-Meier curves were constructed to evaluate overall survival rates, while Cox proportional hazards regression analyses were performed to identify potential predictors of the outcomes.

Nineteen cases of major bleeding were recorded during the follow-up period, resulting in an overall incidence rate of 9.8 per 100 patient-years. Major bleeding became progressively more common in patients with higher disease severity (Child-Pugh class A, B and C: 6.8, 15.4 and 33 cases per 100 patient-years, respectively).

In comparison, 25 thrombotic events were observed and yielded an incidence rate of 12.9 per 100 patient-years. Participants with more severe liver diseases were similarly more likely to suffer from recurrent vascular events.

The same was true for mortality, such as those with Child-Pugh class A diseases were less likely to die than those with class C liver disease. Overall, there were 42 deaths reported with an incidence rate of 17.5 per 100 patient-years.

Multivariable analysis revealed that ascites (hazard ratio [HR], 5.65; 95 percent CI, 1.92–16.64; p=0.002), a history of prior venous thromboembolism (HR, 14.73; 2.11–102.83; p=0.007) and a diagnosis of hepatocellular carcinoma (HR, 6.24; 2.45–15.85; p<0.001) were all associated with a significantly higher risk of mortality.

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Most Read Articles
Tristan Manalac, 4 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 6 days ago
The selective cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) effectively improves influenza symptoms in adolescent patients and those at high risk for influenza complications, according to two subanalyses of the CAPSTONE studies presented at ECCMID 2019.