Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

2 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
4 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, 2 days ago
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.

Outcomes for splanchnic vein thrombosis poor in patients with liver cirrhosis

05 Sep 2018

The risk of long-term and recurrent thrombotic events is elevated in cirrhotic patients with splanchnic vein thrombosis (SVT), a recent study has found.

A total of 604 consecutive SVT patients were enrolled in the study, of whom 149 (median age 59 years; 71.1 percent) were cirrhotic. Incidence rates of major bleeding, all-cause mortality and thrombotic events over a 2-year period were collected. Kaplan-Meier curves were constructed to evaluate overall survival rates, while Cox proportional hazards regression analyses were performed to identify potential predictors of the outcomes.

Nineteen cases of major bleeding were recorded during the follow-up period, resulting in an overall incidence rate of 9.8 per 100 patient-years. Major bleeding became progressively more common in patients with higher disease severity (Child-Pugh class A, B and C: 6.8, 15.4 and 33 cases per 100 patient-years, respectively).

In comparison, 25 thrombotic events were observed and yielded an incidence rate of 12.9 per 100 patient-years. Participants with more severe liver diseases were similarly more likely to suffer from recurrent vascular events.

The same was true for mortality, such as those with Child-Pugh class A diseases were less likely to die than those with class C liver disease. Overall, there were 42 deaths reported with an incidence rate of 17.5 per 100 patient-years.

Multivariable analysis revealed that ascites (hazard ratio [HR], 5.65; 95 percent CI, 1.92–16.64; p=0.002), a history of prior venous thromboembolism (HR, 14.73; 2.11–102.83; p=0.007) and a diagnosis of hepatocellular carcinoma (HR, 6.24; 2.45–15.85; p<0.001) were all associated with a significantly higher risk of mortality.

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Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

2 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
4 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, 2 days ago
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.