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Osteoporosis highly prevalent in COPD patients

08 Aug 2019

The prevalence of osteoporosis among patients with chronic obstructive pulmonary disease (COPD) appears to be high and similar in many countries, according to the results of a meta-analysis.

Researchers searched multiple online databases for studies reporting the prevalence and risk factors for osteoporosis in COPD. Two reviewers conducted eligibility screening, data extraction and quality assessment of the retrieved articles.

The meta-analysis included 58 studies. Pooled global prevalence of osteoporosis in COPD was 38 percent (95 percent CI, 34–43). The likelihood of having the bone disease increased by more than twofold in the presence of COPD (odds ratio [OR], 2.83).

Additional significant risk factors for osteoporosis in COPD patients were low body mass index (<18.5 kg/m2; OR, 4.26) and the presence of sarcopenia (OR, 3.65).

The present data suggest that COPD patients should be regularly screened for osteoporosis and contributing risk factors, the researchers said.

Osteoporosis is one of the major systemic comorbidities of COPD and is associated with significant morbidity. Factors implicated in the pathogenesis of the bone disease include systemic inflammatory, physical inactivity, body composition changes, tobacco exposure, corticosteroids use, hypogonadism, anaemia, COPD exacerbation and hypoxia. [Int J Chron Obstruct Pulmon Dis 2016;11:637-648; Clin Med Insights Circ Respir Pulm Med 2015;9:5-21]

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Most Read Articles
Rachel Soon, 16 Aug 2019

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

3 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
Yesterday
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
6 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.