Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
12 Jan 2020
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
Stephen Padilla, 5 days ago
The Lancet Commission on Hypertension Group has recently released a position statement that contains a list of recommendations for the improvement of accuracy standards for devices that measure blood pressure (BP).

Osteopontin gene expression tied to disease severity in pulmonary arterial hypertension

18 Oct 2019

There appears to be a “highly expressed” osteopontin in the lungs of patients with severe pulmonary arterial hypertension (PAH), and this level of expression is significantly associated with disease severity, according to a study, suggesting a major role for osteopontin in the vascular remodelling process of PAH.

Osteopontin was one of the top five upregulated genes in PAH relative to normal controls. This was confirmed by reverse transcription polymerase chain reaction. Moreover, osteopontin was similar and equally elevated in different PAH subtypes.

Osteopontin gene expression showed a strongly significant association with mean pulmonary arterial pressure (PAP). In ingenuity pathway analysis, osteopontin was found to be involved in functions and networks relevant to angiogenesis, cell death and proliferation of pulmonary artery smooth muscle cells (PA‐SMC). Furthermore, no difference was found in osteopontin serum levels between patients with group I PAH and group II pulmonary hypertension (PH).

In this study, the authors conducted microarray analysis after extracting RNA from explanted lungs in 15 patients with group I PAH who underwent lung transplantation and 11 normal controls. They recorded PAP levels intraoperatively immediately before start of lung transplantion.

Serum osteopontin levels were measured in patients with PAH, group II PH and normal controls on the day of right heart catheterization.

“Osteopontin is a pleiotropic cytokine involved in the proliferation of PA‐SMC,” the authors explained. “Osteopontin is upregulated in the lungs of patients with PH associated with pulmonary fibrosis, suggesting that the lung is a source of osteopontin.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Respirology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
12 Jan 2020
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
Stephen Padilla, 5 days ago
The Lancet Commission on Hypertension Group has recently released a position statement that contains a list of recommendations for the improvement of accuracy standards for devices that measure blood pressure (BP).