Most Read Articles
Stephen Padilla, 2 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
01 Aug 2020
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

Osteopontin gene expression tied to disease severity in pulmonary arterial hypertension

18 Oct 2019

There appears to be a “highly expressed” osteopontin in the lungs of patients with severe pulmonary arterial hypertension (PAH), and this level of expression is significantly associated with disease severity, according to a study, suggesting a major role for osteopontin in the vascular remodelling process of PAH.

Osteopontin was one of the top five upregulated genes in PAH relative to normal controls. This was confirmed by reverse transcription polymerase chain reaction. Moreover, osteopontin was similar and equally elevated in different PAH subtypes.

Osteopontin gene expression showed a strongly significant association with mean pulmonary arterial pressure (PAP). In ingenuity pathway analysis, osteopontin was found to be involved in functions and networks relevant to angiogenesis, cell death and proliferation of pulmonary artery smooth muscle cells (PA‐SMC). Furthermore, no difference was found in osteopontin serum levels between patients with group I PAH and group II pulmonary hypertension (PH).

In this study, the authors conducted microarray analysis after extracting RNA from explanted lungs in 15 patients with group I PAH who underwent lung transplantation and 11 normal controls. They recorded PAP levels intraoperatively immediately before start of lung transplantion.

Serum osteopontin levels were measured in patients with PAH, group II PH and normal controls on the day of right heart catheterization.

“Osteopontin is a pleiotropic cytokine involved in the proliferation of PA‐SMC,” the authors explained. “Osteopontin is upregulated in the lungs of patients with PH associated with pulmonary fibrosis, suggesting that the lung is a source of osteopontin.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Respirology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 2 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
01 Aug 2020
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.