Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Osteoarthritis increases social isolation in older adults

18 Jan 2020

Clinical osteoarthritis (OA) appears to intensify social isolation among elderly adults, a recent study has found.

Researchers conducted a prospective observational study on 1,697 elderly adults (mean age, 73.7±5.3 years; 49.6 percent female) enrolled in the European Project on Osteoarthritis. The Lubben Social Network Scale and the Maastricht Social Participation Profile were used to evaluate social isolation.

Clinical OA was present in 29.6 percent of the participants: 8.4 percent had OA at the hand, 13.6 percent at the hip and/or knee, and 7.6 percent at both hand and hip and/or knee. Nineteen percent (n=382) were deemed to be socially isolated at baseline. Of the remaining 1,585 who were not socially isolated, 13 percent (n=222) developed incident isolation over 12–18 months of follow-up.

Logistic regression analysis adjusted for potential confounders found that clinical OA, either of the hip and/or knee alone or with hand manifestations, is a significant predictor of incident social isolation (odds ratio [OR], 1.47, 95 percent confidence interval [CI], 1.03–2.09; p=0.032). No OA or OA of the hand alone was used as a reference.

Cognitive impairment (OR, 1.90, 95 percent CI, 1.09–3.29; p=0.022) and depression in women (OR, 2.78, 95 percent CI, 1.50–5.15; p=0.001) also emerged as significant risk factors for social isolation. Longer walking time, classified into quartiles, exerted progressively stronger effects (Q2 vs Q1: OR, 2.11, 95 percent CI, 1.36–3.28; Q3 vs Q1: OR, 2.12, 95 percent CI, 1.35–3.33; p=0.001; Q4 vs Q1: OR, 2.06, 95 percent CI, 1.28–3.33; p=0.003).

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.