Most Read Articles
Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.
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The potent and highly selective RET* inhibitor BLU-667 was well-tolerated and exhibited promising clinical activity among patients with advanced, RET-altered solid cancers that progressed despite multikinase inhibitor therapy, according to data presented at AACR 2018.

OSA in primary aldosteronism patients improves with adrenalectomy, medication

04 Sep 2017

Obstructive sleep apnoea (OSA) is common among patients with primary aldosteronism (PA), and adrenalectomy or medical therapy for PA appears to be associated with marked improvements in the sleep disorder, a study has found.

The study included 34 patients with PA (median age 50 years; 61.8 percent male; median body mass index >30 kg m-2) who underwent polysomnography at baseline and after 3 months after treatment.

OSA was not evident in 21 percent of PA patients (apnoea-hypopnea index [AHI] <5), mild in 26 percent (AHI ≥5 and <15), moderate in 24 percent (AHI ≥15 and <30), and severe in the remaining 29 percent (AHI ≥30). AHI correlated with body mass index tertiles, neck circumference and 24-hour urinary sodium.

In 20 patients who underwent repeat polysomnography following treatment for PA—including mineralocorticoid receptor antagonists in 13 patients with bilateral PA and adrenalectomy in seven with unilateral PA—median AHI significantly decreased from 22.5 to 12.3 (p=0.02). A small reduction in neck circumference was also observed with PA treatment (41.6 vs 41.2 cm; p=0.012).

Researchers noted that the present data indicate that OSA in the study population is primarily driven by anatomical factors and aggravated by aldosterone excess in a salt-dependent manner, possibly by inducing increased airways oedema.

Primary aldosteronism is believed to cause hypertension largely through the promotion of sodium and fluid retention. Retention of fluid has been also shown to promote oedema of the soft tissues of the upper airway, thus causing or worsening OSA and providing a plausible mechanistic link. This is supported by the suggestion of a salt dependency in the aldosterone–OSA relationship. [Hypertension 2012;59:167–172; Sci Rep 2015;5:15297; Chest 2013;143:978–983]

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Most Read Articles
Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.
16 Oct 2016
Irritable bowel syndrome and asthma share a bidirectional association, a new study reports. Further, atopy potentially plays a role in the underlying mechanisms of this association.
Audrey Abella, 09 May 2018
The potent and highly selective RET* inhibitor BLU-667 was well-tolerated and exhibited promising clinical activity among patients with advanced, RET-altered solid cancers that progressed despite multikinase inhibitor therapy, according to data presented at AACR 2018.