Most Read Articles
3 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 2 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Orvepitant delivers sustained improvements in chronic refractory cough

18 Sep 2019

Treatment with the neurokinin-1 receptor antagonist orvepitant appears to be safe in patients with chronic refractory cough, yielding sustained improvements in cough frequency and severity, according to the results of the phase II VOLCANO-1 trial.

Thirteen patients with daytime cough frequency of >3 to <250 coughs/hour received orvepitant 30 mg once daily for 4 weeks. Objective cough frequency was measured over 24 hours at several time points: baseline and weeks 1, 4, and 8.

The primary outcome was change in daytime cough frequency at week 4. Secondary outcomes included cough severity score on visual analogue scale (VAS), global ratings of change for cough frequency and severity, and Cough-specific Quality of Life Questionnaire score.

Mean objective daytime cough frequency at baseline was 71.4/hour. This improved by 26 percent at week 4, translating to a decrease of 18.9 coughs/hour (95 percent CI, 9.6–28.3; p<0.001).

The improvement was already evident during the first week of treatment (reduction from baseline of 38 percent or 27.0 coughs/hour, 11.4–42.7; p=0.001) and sustained after drug discontinuation through week 8 (reduction of 29 percent or 20.4 coughs/hour, 3.2–37.5; p=0.020). There were significant, parallel improvements seen in severity VAS and quality of life scores.

These findings show that orvepitant merits further clinical investigation, according to researchers.

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Most Read Articles
3 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 2 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.