Most Read Articles
Rachel Soon, 3 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Jackey Suen, 08 Oct 2018

Adding pertuzumab to trastuzumab plus an aromatase inhibitor (AI) improves progression-free survival (PFS) in patients with HER2-positive metastatic or locally advanced breast cancer, the phase II PERTAIN study has shown.

05 Aug 2019
Use of alpha blockers in the treatment of hypertension in women is associated with an increased risk of hypotension and related events as compared with other blood pressure-lowering drugs, as reported in a recent study.
Laura Kho Sui San , 29 May 2019
Anxiety becomes a pathological disorder when it occurs for no detectable reason, persists and interferes with daily activities like work performance and relationships.

Organ damage, anti-dsDNA antibodies predict belimumab efficacy in lupus

11 Jul 2019

Belimumab treatment for systemic lupus erythematosus (SLE) may induce low disease activity (LDA) and clinical remission in patients with limited or no organ damage, as well as with positive antidouble stranded DNA (anti-dsDNA) titres, according to a study.

The study used data from the BLISS-52 and BLISS-76 trials and included 563 SLE patients (mean age, 37.9 years; 95.7 percent female) who received belimumab 10 mg/kg. Researchers used logistic regression to evaluate the performance of baseline factors in predicting achievement of LDA (assessed using Lupus Low Disease Activity State [LLDAS]) or clinical remission (defined as SLE Disease Activity Index 2000 score of 0) at week 52 from treatment initiation.

Organ damage (assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index [SDI]) reduced the likelihood of attaining LDA (SDI >0: odds ratio (OR), 0.44, 95 percent CI, 0.22–0.90; p=0.024) and the primary LLDAS condition (ie, SLEDAI-2K 4 with no renal activity, pleurisy, pericarditis or fever; SDI >1: OR, 0.46, 0.27–0.77; p=0.004). The association between organ damage and failure to achieve the primary LLDAS condition was attributed mainly to cognitive impairment/psychosis prior to belimumab initiation.

Baseline SDI scores >1 also predicted failure to attain clinical remission (OR, 0.53, 0.30–0.94; p=0.030), with cutaneous damage largely driving this association.

On the other hand, anti-dsDNA positivity increased the probability of attaining clinical remission, along with reduced prednisone intake (7.5 mg/day), by about 80 percent (OR, 1.82, 1.08–3.06; p=0.025). However, cardiovascular damage reduced the probability of such an outcome (OR, 0.13, 0.02–0.97; p=0.047).

The associations observed were independent of age, SLE disease duration or SLE activity grade, the researchers noted, adding that the data overall have important clinical implications with respect to optimization of the use of belimumab.

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Most Read Articles
Rachel Soon, 3 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Jackey Suen, 08 Oct 2018

Adding pertuzumab to trastuzumab plus an aromatase inhibitor (AI) improves progression-free survival (PFS) in patients with HER2-positive metastatic or locally advanced breast cancer, the phase II PERTAIN study has shown.

05 Aug 2019
Use of alpha blockers in the treatment of hypertension in women is associated with an increased risk of hypotension and related events as compared with other blood pressure-lowering drugs, as reported in a recent study.
Laura Kho Sui San , 29 May 2019
Anxiety becomes a pathological disorder when it occurs for no detectable reason, persists and interferes with daily activities like work performance and relationships.