Most Read Articles
Stephen Padilla, 01 Feb 2019
More children are expected to be diagnosed with hypertension based on the new criteria for high blood pressure (HBP) in young people, according to a new study. In addition, the strength of association of HBP with body mass index (BMI) and other medical and behavioural factors has not changed, supporting the validity of the new definition.
29 Nov 2018
Pulmonary hypertension (PH) is associated with underlying risk factors in children with congenital hyperinsulinism (HI) treated with diazoxide, reports a study. Other adverse events, however, do not show any identifiable risk profile.
18 Jan 2019
Azithromycin treatment in children with recurrent asthma-like symptoms acutely disrupts gut microbiota composition, a recent study has found.
14 Jan 2019
The application of mupirocin to multiple body sites of infants appears to be safe and effective for eradicating Staphylococcus aureus carriage in the neonatal intensive care unit setting, a study has found. However, recolonization occurs after 2–3 weeks in a number of infants who remain hospitalized.

Organ complication, CRP value predict severe outcome in paediatric measles

01 Feb 2019

The risk of severe outcome in children with measles, while independent of age, increases in the presence of encephalitis or pancreatitis and elevated C-reactive protein (CRP) values, a study has found.

Researchers reviewed the medical records of 249 children (median age 14.5 months; 51 percent male) hospitalized for measles to investigate the risk factors for severe outcome defined by the presence of long-lasting sequelae, need of intensive care or death.

Of the children, 207 (83 percent) developed any complication and three (1 percent) died. Organ complications, such as in the respiratory tract, liver, pancreas, central nervous system and myocardium, were reported in 135 of the 207 children.

Meanwhile, blood cytopaenia occurred in 120 children, with neutropaenia being more common in those with the B3-genotype vs other genotypes (29.5 percent vs 7.7 percent; p=0.01).

On multivariable regression analysis, the risk of severe outcome was significantly associated with pancreatitis (adjusted odds ratio [aOR], 9.19; p=0.01), encephalitis (aOR, 7.02; p=0.04) and CRP value (aOR, 1.1; p=0.028).

CRP was a significant predictor of complications and severe outcome, with an area under the receiver operating characteristic curve of 0.67 (95 percent CI, 0.52–0.82). CRP values >2 mg/dL were associated with a higher risk of complications (OR, 2.0; 1.15–3.7; p=0.01) or severe outcome (OR, 4.13; 1.43–11.8; p<0.01).

According to current knowledge and World Health Organization indications, measles-related complications and death occur with greater frequency in children aged <5 years and in those with malnutrition, micronutrient deficiency or immunodeficiency. Researchers noted that while the potential effect of bacterial coinfection on CRP is unclear, point-of-care CRP testing might be useful in identifying children requiring hospital management.

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Most Read Articles
Stephen Padilla, 01 Feb 2019
More children are expected to be diagnosed with hypertension based on the new criteria for high blood pressure (HBP) in young people, according to a new study. In addition, the strength of association of HBP with body mass index (BMI) and other medical and behavioural factors has not changed, supporting the validity of the new definition.
29 Nov 2018
Pulmonary hypertension (PH) is associated with underlying risk factors in children with congenital hyperinsulinism (HI) treated with diazoxide, reports a study. Other adverse events, however, do not show any identifiable risk profile.
18 Jan 2019
Azithromycin treatment in children with recurrent asthma-like symptoms acutely disrupts gut microbiota composition, a recent study has found.
14 Jan 2019
The application of mupirocin to multiple body sites of infants appears to be safe and effective for eradicating Staphylococcus aureus carriage in the neonatal intensive care unit setting, a study has found. However, recolonization occurs after 2–3 weeks in a number of infants who remain hospitalized.