Most Read Articles
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Oral–topical treatment regimen an attractive alternative to prednisone in bullous pemphigoid

27 Jan 2019

A treatment regimen containing oral tetracycline and nicotinamide plus topical clobetasol appears to be effective in the treatment of bullous pemphigoid (BP), yielding better survival rates compared with prednisone, according to a study.

The 3-year retrospective study included 106 patients with newly diagnosed BP (mean age 78 years; 64.4 percent female), among whom 59 received tetracycline 1.5 g/daily, nicotinamide 1.2 g/daily and 0.05 percent lesionally administered clobetasol cream (TNC arm), while 47 received prednisone 0.5 mg/kg daily.

Both patient groups achieved median time to disease control after 7 days. The proportion of patients who achieved disease control at week 4 was 93.2 percent in the TNC arm vs 89.1 percent in the prednisone arm.

The median period between complete remission and relapse was 60 days in the TNC group and 90 days in the prednisone group (p=0.84). Within 1 year, significantly more patients in the prednisolone vs TNC group had at least one relapse within 1 year (50 percent vs 32.1 percent; p=0.09).

The 1-year survival was 83 percent in the TNC group and 65.9 percent in the prednisone group (p=0.04), while the corresponding 3-year survival was 71.2 percent and 48 percent (p=0.019).

The present data show that combined treatment with tetracycline, nicotinamide and lesionally administered clobetasol may improve survival rates compared with prednisone in patients with BP, researchers said. Thus, it would be reasonable to initiate this regimen in age-advanced patients with comorbidities and movement difficulties.

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Most Read Articles
Pearl Toh, 3 days ago
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.