Most Read Articles
5 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

3 days ago
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
5 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
3 days ago
The risk factors and outcomes associated with an increased risk of permanent pacing include atrial fibrillation (AF) ablation, multivalve surgery and New York Heart Association (NYHA) functional class III/IV, a recent study has found.

Oral steroids provide clinically insignificant benefits in NAAION

07 Oct 2018

Use of oral steroids in acute nonarteritic anterior ischaemic optic neuropathy (NAAION) does not lead to significant improvements in visual acuity at 6 months, but it significantly enhances resolution of disc oedema and allows greater progress in visual evoked response (VER) parameters, reports a recent study.

A total of 38 patients with acute nondiabetic NAAION were recruited in this randomized double-blind clinical trial that examined the role of oral steroid therapy in the treatment of such condition. Participants were divided into two arms of 19 patients each, with one arm constituting the cases and the other the controls.

NAAION patients received oral steroid therapy and were designated the steroid group, while control participants received placebo and were designated the nonsteroid group. The authors performed best-corrected visual acuity (BCVA), VER and optical coherence tomography (OCT) assessments at baseline, 1 month, 3 months and 6 months after recruitment into the trial.

There were significant improvements in BCVA, VER latency and resolution of disc oedema on OCT parameters over 6 months in both groups.

No statistically significant difference was observed in terms of visual acuity, but VER was better in the steroid group (p=0.011). The steroid group also had a greater percentage improvement in BCVA (p=0.02), VER amplitude (p=0.02) and VER latency (p=0.04), as well as a faster resolution of disc oedema on OCT at 1-month follow-up.

“This subtle benefit of oral steroids in NAAION is clinically unimportant and does not provide support for its use,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

3 days ago
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
5 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
3 days ago
The risk factors and outcomes associated with an increased risk of permanent pacing include atrial fibrillation (AF) ablation, multivalve surgery and New York Heart Association (NYHA) functional class III/IV, a recent study has found.