Most Read Articles
01 Nov 2019
Discontinuation of antitumour necrosis factor (anti-TNF) therapy for perianal Crohn’s disease is highly likely to lead to relapse, with some patients even requiring defunctioning surgery, according to a study conducted across Asia.
Pearl Toh, 22 Oct 2019
Among patients with a large perforated peptic ulcer (PPU), undergoing omental patch repair confers comparable perioperative outcomes as gastrectomy, a retrospective local study shows.
Prof. Khean-Lee Goh, Yong Yeh Lee, 15 Oct 2019

The global community is celebrating World Stomach Day on October 2, now in its second year, and the date itself reminds us of the very first report of Helicobacter pylori in 1982.

Oral nano vitamin D supplementation eases disease activity, severity in ulcerative colitis

17 Nov 2019

Supplementation with oral nano vitamin D appears to moderate disease activity and severity grade of patients with active ulcerative colitis (UC), suggests a study, adding that this association is more evident in those achieving a target vitamin D level of 40 ng/mL.

The investigators assessed the effect of oral nano vitamin D3 supplementation on disease activity in active UC (UC disease activity index [UCDAI] ≥3) by randomizing patients with active UC and vitamin D <40 ng/mL to receive either oral nano vitamin D (60,000 IU/dx8 d) or placebo.

Participants were then evaluated for disease activity (UCDAI scores, C-reactive protein, erythrocyte sedimentation rate and faecal calprotectin) at baseline and at 4 weeks. The response was defined as a 3-point reduction in UCDAI score at 4 weeks and decrease in inflammatory markers.

The median vitamin D levels rose from 15.4 to 40.83 mg/dL in the vitamin D group (p≤0.001) and marginally from 13.45 to 18.85 mg/dL (p=0.027) in the control group. Response was more prevalent among vitamin D patients as compared with controls (53 percent vs 13 percent; p=0.001).

Increase in vitamin D levels led to reductions in UCDAI score (p≤0.001; ρ=–0.713), C-reactive protein (p0.001; ρ=–0.603) and calprotectin (p=0.004; ρ=–0.368). Patients who achieved the target vitamin D level of >40 ng/mL (n=17) were more likely to reach a 3-point reduction in UCDAI (80 percent vs 20 percent; p≤0.001) and a decrease in severity grade from 60 percent to 35 percent (p=0.038).

Moreover, vitamin D administration (odds ratio [OR], 9.17, 95 percent confidence interval [CI], 2.02–41.67) and baseline histologic activity (OR, 1.92, 95 percent CI, 1.2–3.08) were independently associated with response.

“Vitamin D possesses anti-inflammatory properties and could be beneficial in UC,” the investigators said.

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Most Read Articles
01 Nov 2019
Discontinuation of antitumour necrosis factor (anti-TNF) therapy for perianal Crohn’s disease is highly likely to lead to relapse, with some patients even requiring defunctioning surgery, according to a study conducted across Asia.
Pearl Toh, 22 Oct 2019
Among patients with a large perforated peptic ulcer (PPU), undergoing omental patch repair confers comparable perioperative outcomes as gastrectomy, a retrospective local study shows.
Prof. Khean-Lee Goh, Yong Yeh Lee, 15 Oct 2019

The global community is celebrating World Stomach Day on October 2, now in its second year, and the date itself reminds us of the very first report of Helicobacter pylori in 1982.