Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Pearl Toh, Yesterday
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 5 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.

Oral corticosteroid use during pregnancy poses no risk of congenital heart defects

26 Nov 2019

Exposure to oral corticosteroids during pregnancy bears no harm to the offspring in terms of the risk of congenital heart defects (CHDs), a study reports.

Using data from a register-based nationwide prevalence study including all live singleton births in Denmark, researchers looked at 1,194,687 mother-and-child pairs to assess the risk of offspring CHDs in relation to the mothers’ use of oral corticosteroids in early pregnancy.

A total of 2,032 individuals (0.17 percent) had a mother who filled a prescription for oral corticosteroids during the 0–8-week period after conception, whereas 1,142,091 (96 percent) had a mother who never used the drugs.

CHDs were documented in 11,094 individuals, yielding a prevalence rate of 93 per 10,000. The crude prevalence was higher in individuals whose mothers filled a prescription for oral corticosteroids in weeks 0–8 after conception than in those whose mothers were never exposed to the drug (32 vs 10,534; prevalence, 157 vs 92 per 10,000; prevalence ratio [PR], 1.72, 95 percent confidence interval [CI] 1.21–2.44).

However, the PR was attenuated following adjustments for maternal age, birth order, calendar year and other covariates associated with corticosteroid exposure and CHD (1.29, 95 percent CI, 0.90–1.84; p=0.16). Propensity score-matched analysis yielded similar results (PR, 1.38, 95 percent CI, 0.95–2.02).

In light of the findings, the researchers pointed out that there is no reason to refrain from corticosteroid treatment during early pregnancy, especially when there is a clear and pertinent indication.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Pearl Toh, Yesterday
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 5 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.