Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 19 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.

Opioid prescriptions for minor urologic surgeries up risk for persistent use

07 Jan 2020

Men who are prescribed opioids for minor urologic surgeries are more likely to develop persistent long-term opioid use, a recent study has found.

Researchers retrospectively assessed 91,083 men who underwent minor urological procedure, such as vasectomy, urethrotomy, circumcision or spermatocelectomy. The primary outcome was persistent opioid use, defined as the filling of a prescription 9–15 months after the surgery. Admission for opioid overdose was set as a secondary outcome.

More than a third of the participants (35 percent; n=32,174; median age, 39.0 years) filled an opioid prescription within 5 days of the index procedure; majority (96 percent) were claimed on the first day. Immediate-release codeine (70 percent) was the predominant medication, followed by oxycodone (14 percent) and tramadol (13 percent).

Logistic regression analysis found that those who took opioid medication after the procedure were significantly more likely to be at risk of persistent opioid use even a year after the operation (adjusted odds ratio [OR], 1.43, 95 percent confidence interval [CI], 1.26–1.62; p<0.001). These men repeatedly filled opioid prescriptions 9–15 months after the index procedure.

Moreover, the risk for emergency department visits or hospital admissions for opioid overdose was significantly elevated in these participants (OR, 3.01, 95 percent CI, 1.55–5.85; p<0.001). The principal findings were robust across sensitivity analyses.

“The number needed to harm with postprocedure opioids is concerning. For every 148 men who received a postprocedure opioid prescription, one had evidence of new persistent opioid use a year later,” the researchers pointed out.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
Roshini Claire Anthony, 19 hours ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
09 Jan 2020
Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.