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Pearl Toh, 03 Jan 2020
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Once-weekly carfilzomib dosing preferable for relapsed/refractory multiple myeloma

3 days ago

The once-weekly carfilzomib regimen of Kd70 mg/m2 for relapsed or refractory multiple myeloma (RRMM) is more favourable than the twice-weekly Kd27 mg/m2, as the former is associated with delayed symptom worsening and greater patient-reported convenience and satisfaction, according to a recent study.

The study used data from the open-label, phase III ARROW trial involving 478 adult RRMM patients who were previously treated with 2–3 prior lines of therapy, including a proteasome inhibitor and an immunomodulatory agent. Of the patients, 240 had been randomized to the once-weekly Kd70 mg/m2 regimen and 238 to the twice-weekly Kd27 mg/m2 regimen.

Researchers compared patient-reported convenience/satisfaction collected at cycle 2, day 1. They also administered European Organization for Research and Treatment of Cancer QOL Questionnaire (QLQ-C30), MM-module (QLQ-MY20) and EuroQoL-5 Dimensions-5 Levels (EQ-5D-5L) questionnaires at baseline and then every other cycle. Patient-reported outcome analyses included 469 patients.

Compared with twice-weekly, the once-weekly regimen conferred greater convenience (odds ratio [OR], 4.98; p<0.001) and satisfaction (OR, 2.41; p=0.059). Fewer patients in the once-weekly arm exhibited a clinically meaningful deterioration in QLQ-C30 Global Health Status/QOL (34.2 percent vs 40.3 percent).

Time from randomization to first deterioration was longer with the once-weekly vs twice-weekly regimen for the following outcomes: QLQ-C30 fatigue (hazard ratio [HR], 0.79; p=0.035), QLQ-MY20 disease symptoms (HR, 0.67; p=0.008), EQ-5D-5L index score (HR, 0.58; p=0.002) and EQ-5D-5L Visual Analog Scale (HR, 0.75; p=0.031).

The present data show that the once-weekly Kd70 mg/m2 carfilzomib dose is superior and convenient, delivering more favourable health-related quality of life in RRMM patients compared with the commonly used Kd27 mg/m2 dose, the researchers said. The once-weekly regimen is therefore positioned to be an important alternative in clinical practice.

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Most Read Articles
Pearl Toh, 03 Jan 2020
Antibiotic resistance of Helicobacter (H.) pylori has more than doubled in Europe in the past two decades, raising alarm on the gravity of the issue of growing bacterial resistance to commonly-used antibiotics, a study presented at UEG Week 2019 has shown.
02 Dec 2019
Utilizing a clinical pharmacist specialist in a hepatitis C virus (HCV) treatment clinic may help improve drug therapy management of HCV-infected patients treated with direct-acting antivirals (DAAs), suggests a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
4 days ago
The use of folic acid in addition to enalapril in the treatment of patients with hypertension yields a modest increase in lifetime stroke-free survival, a study has found.