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Omega-3 supplementation confers no benefit for vascular events in diabetics

23 Sep 2018

Supplementation with n−3 or omega-3 fatty acids does not help prevent serious vascular events in diabetic patients without evidence of cardiovascular disease at baseline, according to a study.

A total of 15,480 patients (mean age 63.3 years; 62.6 percent male) with diabetes but without atherosclerotic cardiovascular disease were randomized to receive 1-g capsules containing either omega-3 fatty acids (n=7,740) or matching placebo (olive oil; n=7,740) daily.

The incidence of a primary outcome of a first serious vascular event (ie, nonfatal myocardial infarction or stroke, transient ischaemic attack, or vascular death, excluding confirmed intracranial haemorrhage) between the two groups was similar, occurring in 689 patients (8.9 percent) in the fatty acid group and in 712 (9.2 percent) in the placebo group (rate ratio, 0.97; 95 percent CI, 0.87–1.08; p=0.55) during a mean follow-up of 7.4 years.

Likewise, the secondary outcome of a composite of serious vascular event or revascularization was comparable between the fatty acid and placebo groups (882 [11.4 percent] vs 887 [11.5 percent], respectively; rate ratio, 1.00; 0.91–1.09).

No significant between-group difference was observed in death from any cause, occurring in 752 patients (9.7 percent) in the fatty acid group and in 788 (10.2 percent) in the placebo group (rate ratio, 0.95; 0.86–1.05), as well as in the rates of nonfatal serious adverse events.

The present data, together with results of earlier randomized trials involving patients with and those without diabetes, are in opposition to the current recommendations for routine dietary supplementation with n−3 fatty acids to prevent vascular events, researchers said.

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Most Read Articles
Tristan Manalac, 5 days ago
Left ventricular assist devices (LVADs) can reverse pulmonary hypertension secondary to left heart disease regardless of baseline pulmonary vascular resistance, according to a new study.
11 May 2019
Acute kidney injury (AKI) commonly occurs within a year after cancer diagnosis in paediatric patients and is tied to long-term deteriorations in renal function, a recent study has found.
11 May 2019
Women practicing exclusive breastfeeding for 6 months achieve greater postpartum weight loss compared with those exclusively breastfeeding for a shorter duration, according to data from the MILK* study.
Pearl Toh, 13 May 2019
The selective cap-dependent endonuclease inhibitor baloxavir marboxil (hereafter baloxavir) effectively improves influenza symptoms in adolescent patients and those at high risk for influenza complications, according to two subanalyses of the CAPSTONE studies presented at ECCMID 2019.