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Omega-3 fatty acids ineffective against bronchopulmonary dysplasia in preemies

07 Jul 2019

Use of omega-3 long-chain polyunsaturated fatty acids (N-3 LCPUFAs) proves to be unsuccessful at preventing bronchopulmonary dysplasia (BPD) in preterm infants, according to the results of a meta-analysis.

Researchers searched multiple online databases for randomized controlled trials (RCTs) evaluating the effect of intervention with N-3 LCPUFAs (initiated within 1 month of birth) on the incidence of BPD or oxygen dependency for 28 days after birth or 36 weeks’ postmenstrual age in preterm infants (<37 weeks of gestation).

The meta-analysis included 14 trials, which involved 3,531 preterm infants in total. Pooled data revealed that N-3 LCPUFAs conferred no beneficial effect on the incidence of BPD in preterm infants (risk ratio, 0.99; 95 percent CI, 0.84–1.18; p=0.93).

Results were similar in subgroup analyses stratified by gestational age, birth weight, dosage of docosahexaenoic acid and duration of intervention.

The current findings provide no supporting evidence for current recommendations to administer N-3 LCPUFAs routinely, according to the researchers, who acknowledged that the main limitation of the meta-analysis is that the populations, protocols and pharmaceutical ingredients of N-3 LCPUFAs vary among the included trials.

More studies with larger sample sizes and long-term follow-up data are needed to establish whether the efficacy of N-3 LCPUFAs on BPD is affected by populations, protocols and the specific pharmaceutical ingredients of N-3 LCPUFAs, they added.

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Most Read Articles
5 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 2 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
5 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
2 days ago
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.