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24 May 2020
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Roshini Claire Anthony, 2 days ago

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Omega-3 fatty acid infusions do not protect against complications in liver surgery

05 Mar 2020

The infusion of two single doses of Omega-3 polyunsaturated fatty acids before and after liver surgery does not appear to reduce the risk of complications, a new study has found.

Researchers conducted a multi-centre, double-blind, randomized, placebo-controlled trial including 261 patients undergoing liver surgery. Intravenous Omega-3 fatty acids were given to 132 patients (median age, 59 years; 47 percent male) while the remaining 129 (median age, 60 years; 52 percent male) received placebo. The primary outcome was the incidence of postoperative complications.

The mortality rates in the Omega-3 and placebo groups were 4 percent and 2 percent, respectively, yielding a nonsignificant difference in the risk of death (p=0.447).

Almost half of each of group developed any complication (46 percent in the Omega-3 arm and 43 percent in the placebo arm), such that the resulting risk estimate failed to reach significance (odds ratio [OR], 0.89, 95 percent confidence interval [CI], 0.53–1.50; p=0.709).

The same was true for major complications, as defined by a Clavien-Dindo grade of at least 3b (12 percent vs 10 percent; OR, 0.81, 95 percent CI, 0.34–1.89; p=0.69). These findings were robust to subgroup analyses.

In addition, Omega-3 fatty acid infusion also resulted in an increase in median triglyceride levels, which remained elevated until after the second dose. No such changes were reported for platelets and the international normalized ratio.

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Most Read Articles
24 May 2020
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Roshini Claire Anthony, 2 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 3 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.