Most Read Articles
27 Jan 2018
There is an over-representation of women in published reports of celecoxib drug-induced liver injury (DILI), according to a recent study. Latency has been shown to be short (<3 months) in most patients, but some of them may present with DILI after prolonged use of celecoxib.
22 Mar 2016
A recent study showed that routine use of alpha galactosidase (AG) has no benefit in irritable bowel syndrome (IBS) patients.
15 Nov 2017
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
Rachel Soon, 14 Dec 2016

More well-designed studies are needed to confirm the benefits of various probiotics currently promoted for gut health, according to experts.

Olmesartan vs other ARBs may carry increased risk of enteropathy

09 Feb 2018

There may be an increased rate of enteropathy in users of olmesartan than in users of other angiotensin II receptor blockers (ARBs), a study suggests. However, the absolute incidence rate appears to be low overall.

Researchers looked at a cohort of 1,928,469 patients (mean age 55 years; 58 percent female) who initiated ARBs, among whom 350,790 initiated olmesartan (18 percent) and 1,577,679 initiated other ARBs (82 percent). Commonly used ARBs other than olmesartan were valsartan (n=679,039), losartan (n=543,797), irbesartan (n=171,239) and telmisartan (n=123,089). Most patients had hypertension (77 percent), while 39 percent had dyslipidaemia and 28 percent had diabetes.

During a mean follow-up of 282 days of ARB exposure, coeliac disease developed in 1,227 patients, malabsorption in 2,102, concomitant diagnoses of diarrhoea and weight loss were documented in 2,467, and noninfectious enteropathy in 42,440.

In Cox regression models, the crude hazard ratios with olmesartan vs other ARBs were 1.21 (95 percent CI, 1.05–1.40) for coeliac disease, 1.00 (0.88–1.13) for malabsorption, 1.22 (1.10–1.36) for concomitant diagnoses of diarrhoea and weight loss, and 1.04 (1.01–1.07) for noninfectious enteropathy.

However, after propensity-score matching, olmesartan use was associated with significantly increased rates of coeliac disease (HR, 1.21; 1.05–1.40), concomitant diagnoses of diarrhoea and weight loss (HR, 1.22; 1.10–1.36) and noninfectious enteropathy (HR, 1.04; 1.01–1.07).

Subgroup analyses showed that the risk of enteropathy-related outcomes was greater for patients aged 65 years (eg, HR for coeliac disease, 1.57; 1.20–2.05), for those receiving treatment for >1 year (eg, HR for coeliac disease, 1.62; 1.24–2.12) and for those receiving higher cumulative olmesartan doses (eg, HR for coeliac disease, 1.78; 1.33–2.37).

The present data underscore a need to acknowledge the potential olmesartan-associated enteropathy in clinical practice, researchers said. “Until more evidence is available, clinicians should consider olmesartan as a potential cause when evaluating patients with enteropathy and should consider alternative ARBs for these patients.”

Additional prospective studies with primary data on sprue-like enteropathy outcomes, including histology and serology results, are warranted to comprehensively evaluate this safety issue, they added.

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Most Read Articles
27 Jan 2018
There is an over-representation of women in published reports of celecoxib drug-induced liver injury (DILI), according to a recent study. Latency has been shown to be short (<3 months) in most patients, but some of them may present with DILI after prolonged use of celecoxib.
22 Mar 2016
A recent study showed that routine use of alpha galactosidase (AG) has no benefit in irritable bowel syndrome (IBS) patients.
15 Nov 2017
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
Rachel Soon, 14 Dec 2016

More well-designed studies are needed to confirm the benefits of various probiotics currently promoted for gut health, according to experts.