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12 May 2016

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Rachel Soon, 18 Jan 2017

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Jairia Dela Cruz, 19 Oct 2017
Having both type 1 diabetes and coeliac disease (CD) autoimmunity in early childhood appears to be more common than expected, with the development of islet autoantibodies (IAs) conferring a significant risk of subsequent tissue transglutaminase autoantibodies (tTGAs), according to data from the TEDDY* study.
Pank Jit Sin, 25 Nov 2015
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Olmesartan vs other ARBs may carry increased risk of enteropathy

09 Feb 2018

There may be an increased rate of enteropathy in users of olmesartan than in users of other angiotensin II receptor blockers (ARBs), a study suggests. However, the absolute incidence rate appears to be low overall.

Researchers looked at a cohort of 1,928,469 patients (mean age 55 years; 58 percent female) who initiated ARBs, among whom 350,790 initiated olmesartan (18 percent) and 1,577,679 initiated other ARBs (82 percent). Commonly used ARBs other than olmesartan were valsartan (n=679,039), losartan (n=543,797), irbesartan (n=171,239) and telmisartan (n=123,089). Most patients had hypertension (77 percent), while 39 percent had dyslipidaemia and 28 percent had diabetes.

During a mean follow-up of 282 days of ARB exposure, coeliac disease developed in 1,227 patients, malabsorption in 2,102, concomitant diagnoses of diarrhoea and weight loss were documented in 2,467, and noninfectious enteropathy in 42,440.

In Cox regression models, the crude hazard ratios with olmesartan vs other ARBs were 1.21 (95 percent CI, 1.05–1.40) for coeliac disease, 1.00 (0.88–1.13) for malabsorption, 1.22 (1.10–1.36) for concomitant diagnoses of diarrhoea and weight loss, and 1.04 (1.01–1.07) for noninfectious enteropathy.

However, after propensity-score matching, olmesartan use was associated with significantly increased rates of coeliac disease (HR, 1.21; 1.05–1.40), concomitant diagnoses of diarrhoea and weight loss (HR, 1.22; 1.10–1.36) and noninfectious enteropathy (HR, 1.04; 1.01–1.07).

Subgroup analyses showed that the risk of enteropathy-related outcomes was greater for patients aged 65 years (eg, HR for coeliac disease, 1.57; 1.20–2.05), for those receiving treatment for >1 year (eg, HR for coeliac disease, 1.62; 1.24–2.12) and for those receiving higher cumulative olmesartan doses (eg, HR for coeliac disease, 1.78; 1.33–2.37).

The present data underscore a need to acknowledge the potential olmesartan-associated enteropathy in clinical practice, researchers said. “Until more evidence is available, clinicians should consider olmesartan as a potential cause when evaluating patients with enteropathy and should consider alternative ARBs for these patients.”

Additional prospective studies with primary data on sprue-like enteropathy outcomes, including histology and serology results, are warranted to comprehensively evaluate this safety issue, they added.

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Most Read Articles
12 May 2016

A study published in Science shows new strains of microbes from the donor were more likely to colonize the patient’s intestines if that particular species exists in the patient’s gut.

Rachel Soon, 18 Jan 2017

Patients infected with Helicobacter pylori strains derived from different geographical human ancestries than their own are likely to develop more severe symptoms which include gastric cancers, says an expert.

Jairia Dela Cruz, 19 Oct 2017
Having both type 1 diabetes and coeliac disease (CD) autoimmunity in early childhood appears to be more common than expected, with the development of islet autoantibodies (IAs) conferring a significant risk of subsequent tissue transglutaminase autoantibodies (tTGAs), according to data from the TEDDY* study.
Pank Jit Sin, 25 Nov 2015
The many species of bacteria living in the human gut compete with each other to keep their human host healthy, scientists suggest.