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Stephen Padilla, 28 Nov 2017
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Older men with anaemia prone to fracture independent of BMD

24 Jul 2017

Older men with anaemia have a 57- to 72-percent increased risk of nonspine fracture independent of bone mineral density (BMD) and bone loss, reports a new study performed in six communities in the United States.

Researchers conducted a prospective analysis (from baseline to visit 3) and a cross-sectional analysis (at visit 3) in the Osteoporotic Fracture in Men—a multisite, longitudinal cohort study—involving a total of 3,632 community-dwelling men (aged ≥65 years) who were able to walk unassisted, did not have hip replacement or fracture, and had complete blood cell counts at visit 3 (2007 through 2009).

The main outcome measures were adjudicated spine and nonspine fractures during a median follow-up of 7.2 years. Multivariable models included analytic baseline characteristics associated with fractures or anaemia (defined as haemoglobin <12 g/dL).

An association existed between anaemia and increased risk of any fracture (hazard ratio [HR], 1.67; 95 percent CI, 1.26 to 2.21) and nonspine fracture (HR, 1.70; 1.25 to 2.31). A model including change in BMD slightly weakened the association with any (HR, 1.60; 1.20 to 2.13) and nonspine fractures (HR, 1.57; 1.14 to 2.15).

On the other hand, inclusion of the absolute BMD showed no significant change in the association between anaemia and fracture. Furthermore, there was no association between anaemia and spine fracture.

“Extremely low hemoglobin values have been linked to increased fracture risk at different sites. However, careful assessment of clinically defined anemia and fracture risk is lacking,” researchers noted.

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Most Read Articles
Stephen Padilla, 28 Nov 2017
A dietary pattern rich in fresh and dried fruits, nuts and seeds, vegetable oils, and low-fat dairy products appears to lower the incidence rate of insulin resistance, according to an Iran study.
28 Apr 2018
Treatment with teriparatide increases periostin secretion, but it is unclear whether such increase facilitates the effect of the drug on bone, reports a recent study.
Jairia Dela Cruz, 03 Apr 2018
A small cohort study presented at the Royal College of Obstetricians & Gynaecologists (RCOG) World Congress 2018 has reported a 5-year diabetic ketoacidosis (DKA) incidence rate of 4.16 percent in pregnant women with type 1 diabetes mellitus (T1DM), with generally good maternal and neonatal outcomes.
24 Apr 2018
A subclinical inflammatory state resulting from increased adiposity and metabolic dysfunction appears to contribute to breast cancer pathogenesis in Asian women, a Taiwan study has found.