Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Old age, metastatic cancer predict cisplatin-induced nephrotoxicity

12 Nov 2020

Age >65 years and metastatic cancer are significantly associated with cisplatin-induced nephrotoxicities, a recent study has found. An association also exists between cumulative dose and nephrotoxicity or digestive toxicity.

“Cisplatin is a cytotoxic drug that triggers several toxicities,” the authors said. “However, nephrotoxicity and ototoxicity remain major clinical limitations.”

A prospective descriptive study was carried out for 4 months to examine the incidence of chemotherapy toxicity induced by cisplatin and to analyse the influence of risk factors in the Tunisian population. Patients with pathologically confirmed malignancies and treated with cisplatin-regimen chemotherapy were included in the analysis.

The authors graded nephrotoxicity and digestive toxicity based on the World Health Organization toxicity scale and scored ototoxicity in accordance with the Common Terminology Criteria for Adverse Events. They also performed a multivariate logistic regression analysis to assess the influence of clinical variables on cisplatin-induced toxicity.

Of the 150 patients included, 44 percent developed cisplatin-regimen toxicity (15 percent cisplatin-induced nephrotoxicity, 9 percent cisplatin-induced ototoxicity, and 27 percent digestive toxicity). Multivariate analysis revealed that age >65 years (odds ratio [OR], 6.129; p=0.010), metastatic cancer (OR, 0.171; p=0.007), and cumulative dose (OR, 1.004 mg/m2; p=0.042) were strong risk factors for cisplatin-induced nephrotoxicity.

In addition, the cumulative dose was independently prognostic of digestive toxicity (OR, 0.997; p=0.002).

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Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.