Most Read Articles
15 Feb 2020
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Yesterday
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Off-label dupilumab safe, effective for atopic dermatitis in kids

13 Feb 2020

Off-label dupilumab shows potential in the treatment of atopic dermatitis (AD) in children, although appropriate dosing recommendations have yet to be established, suggests a new study.

Researchers performed a multicentre retrospective review including 124 paediatric AD patients (mean age at initiation, 13.0±3.9 years; 32.3 percent female) with moderate-to-severe disease. Qualitative interpretation for symptom improvement, as judged by the physician and documented in the medical record, was translated into a 5-point score and set as the primary outcome.

After a 9-week delay, 89.5 percent (n=111) of the participants were able to initiate dupilumab treatment. The remaining patients (n=13) failed to receive treatment based on their payer denial to cover the cost. The mean loading dose was 8.7±2.2 mg/kg.

At baseline, majority (70.5 percent) of the patients had severe disease, while 29.5 percent had moderate AD. Over a mean follow-up duration of 9 months, the children received an average of 16.4 doses. At the end of the study, majority (64.3 percent) of the patients showed improvements in investigator global assessment scores of at least 2 points.

In comparison, 22.1 percent of children showed a 1-point improvement while 12.6 percent experienced no change in symptoms. Most of the participants believed their eczema had eased and wanted to continue taking dupilumab.

Adverse events occurred rarely. The most common of which was worsening conjunctivitis, detected in 10 patients. There were two cases of viral upper respiratory infection, three injection site reactions and six facial eruptions. One patient discontinued treatment due to lack of response at 6 months.

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Most Read Articles
15 Feb 2020
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Yesterday
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.