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Jairia Dela Cruz, 2 days ago
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Off-label dupilumab safe, effective for atopic dermatitis in kids

13 Feb 2020

Off-label dupilumab shows potential in the treatment of atopic dermatitis (AD) in children, although appropriate dosing recommendations have yet to be established, suggests a new study.

Researchers performed a multicentre retrospective review including 124 paediatric AD patients (mean age at initiation, 13.0±3.9 years; 32.3 percent female) with moderate-to-severe disease. Qualitative interpretation for symptom improvement, as judged by the physician and documented in the medical record, was translated into a 5-point score and set as the primary outcome.

After a 9-week delay, 89.5 percent (n=111) of the participants were able to initiate dupilumab treatment. The remaining patients (n=13) failed to receive treatment based on their payer denial to cover the cost. The mean loading dose was 8.7±2.2 mg/kg.

At baseline, majority (70.5 percent) of the patients had severe disease, while 29.5 percent had moderate AD. Over a mean follow-up duration of 9 months, the children received an average of 16.4 doses. At the end of the study, majority (64.3 percent) of the patients showed improvements in investigator global assessment scores of at least 2 points.

In comparison, 22.1 percent of children showed a 1-point improvement while 12.6 percent experienced no change in symptoms. Most of the participants believed their eczema had eased and wanted to continue taking dupilumab.

Adverse events occurred rarely. The most common of which was worsening conjunctivitis, detected in 10 patients. There were two cases of viral upper respiratory infection, three injection site reactions and six facial eruptions. One patient discontinued treatment due to lack of response at 6 months.

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Most Read Articles
Jairia Dela Cruz, 2 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
11 Sep 2020
Men who use calcium channel blockers (CCBs) are at risk of developing prostate cancer, and the risk increases with the duration of CCB exposure, according to the results of a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
4 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.