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Ofatumumab a safe, effective alternative in B cell–depletion therapy

16 Apr 2018

Ofatumumab appears to be effective and well-tolerated in the treatment of patients with long-standing systemic lupus erythematosus (SLE), offering an alternative to the B cell–depleting agent rituximab, according to a study.

The single-centre study included 16 patients who received ofatumumab, with 50 percent having prior exposure to cyclophosphamide and rituximab (median cumulative dose, 4 g). However, two patients were unable to complete treatment due to significant infusion reactions to ofatumumab, and were therefore excluded from the analysis.

Of the 14 patients (median age 34 years; median duration of SLE, 9.2 years), 12 achieved B cell depletion with ofatumumab. Indications were lupus nephritis (LN) in 12 patients, extra-renal flare in one and remission maintenance in the remaining patient. Treatment was associated with improvements in serological markers of disease activity, including antinuclear antibody, antidouble stranded DNA antibody and complement levels.

In the subgroup of patients treated for LN, half showed response and achieved renal remission by 6 months. Of the six nonresponders, one was retreated with ofatumumab and subsequently achieved remission, while the remaining five had progressive disease that was unresponsive to augmented immunosuppression with cyclophosphamide.

During a median follow-up of 28 months, five grade III infections were documented. No malignancies or deaths occurred.

According to researchers, ofatumumab is a potential alternative in patients who are intolerant of rituximab, with the drug proving to be safe and effective at inducing B cell depletion, with subsequent clinical responses.

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Most Read Articles
5 days ago
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
6 days ago
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
3 days ago
Patients with chronic kidney disease appear to be at greater risk of developing type 2 diabetes mellitus (T2DM) compared with the general population, with predictors including poor baseline glycaemic control and family history of diabetes mellitus, a study has found.