Most Read Articles
Tristan Manalac, 5 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 4 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
3 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.
Pearl Toh, 21 hours ago

Dr Paul Chiam, a senior consultant cardiologist at The Heart & Vascular Centre, Mount Elizabeth Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing hypertension in the primary care setting.

Ofatumumab a safe, effective alternative in B cell–depletion therapy

16 Apr 2018

Ofatumumab appears to be effective and well-tolerated in the treatment of patients with long-standing systemic lupus erythematosus (SLE), offering an alternative to the B cell–depleting agent rituximab, according to a study.

The single-centre study included 16 patients who received ofatumumab, with 50 percent having prior exposure to cyclophosphamide and rituximab (median cumulative dose, 4 g). However, two patients were unable to complete treatment due to significant infusion reactions to ofatumumab, and were therefore excluded from the analysis.

Of the 14 patients (median age 34 years; median duration of SLE, 9.2 years), 12 achieved B cell depletion with ofatumumab. Indications were lupus nephritis (LN) in 12 patients, extra-renal flare in one and remission maintenance in the remaining patient. Treatment was associated with improvements in serological markers of disease activity, including antinuclear antibody, antidouble stranded DNA antibody and complement levels.

In the subgroup of patients treated for LN, half showed response and achieved renal remission by 6 months. Of the six nonresponders, one was retreated with ofatumumab and subsequently achieved remission, while the remaining five had progressive disease that was unresponsive to augmented immunosuppression with cyclophosphamide.

During a median follow-up of 28 months, five grade III infections were documented. No malignancies or deaths occurred.

According to researchers, ofatumumab is a potential alternative in patients who are intolerant of rituximab, with the drug proving to be safe and effective at inducing B cell depletion, with subsequent clinical responses.

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Most Read Articles
Tristan Manalac, 5 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 4 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
3 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.
Pearl Toh, 21 hours ago

Dr Paul Chiam, a senior consultant cardiologist at The Heart & Vascular Centre, Mount Elizabeth Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing hypertension in the primary care setting.