Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Oestrogen therapy may promote development of cutaneous melanoma

06 Dec 2019

Use of oestrogen therapy alone appears to contribute to an increased risk of developing cutaneous melanoma, although the addition of progestins may counteract this unfavourable effect, a study has found.

Researchers used data from the national Medical Reimbursement Registry and those linked to the Finnish Cancer Registry and looked at all women who had purchased hormone therapy between 1994 and 2007.

A total of 293,570 women aged 50 years had used hormone therapy for at least 6 months. Among them, there were 1,695 incident cutaneous melanoma cases recorded over a mean follow-up of 15.6 years.

The standardized incidence ratios (SIR) for cutaneous melanoma were 1.20 (95 percent confidence interval [CI], 1.06–1.35) in the group of women that used unopposed oestrogen therapy and 1.00 (95 percent CI, 0.87–1.14; p-heterogeneity=0.04) in the group that used combined oestrogen–progestin therapy (EPT) for 6–59 months.

Meanwhile, SIRs for women who used oestrogen therapy and EPT for at least 60 months were 1.37 (95 percent CI, 1.22–1.52) and 1.23 (95 percent CI, 1.13–1.34; p-heterogeneity=0.15), respectively.

Estimates did not significantly differ between oral and transdermal administrations, nor by doses of oestrogens.

The present data are in line with previous reports stating that the use of unopposed oestrogens in menopause heightens the risk of cutaneous melanoma, while the addition of progestins might prove beneficial, according to the researchers.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.