Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
Yesterday
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 2 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.

Oestrogen status modifies relationship between renal cell carcinoma risk and obesity in women

09 Sep 2018
The obesity epidemic hits Malaysia hard with cardiovascular disease occurring during younger ages.

Oestrogen status appears to be an important modifying factor for the interaction between obesity and renal cell carcinoma (RCC) risk in women, a recent study has shown. Specifically, high body mass index (BMI) is associated with elevated RCC risk in pre- but not postmenopausal women.

The study included 445 female RCC patients (mean age 53.4±12.1 years) and 508 age-matched cancer-free controls (mean age 52.3±12.5 years). Immunohistochemistry was used to determine the expression levels of oestrogen receptor-β and insulin-like growth factor-1 receptor in RCC tissues.

Setting a BMI cutoff of 25 kg/m2, researchers showed that RCC was significantly common in patients who were overweight than in those who were not (67.27 percent vs 77.60 percent; p=0.029). A similar trend was obtained for quartiles of waist circumference: there were more RCC patients than controls in the highest quartile (21.82 percent vs 11.45 percent; p=0.001).

Interestingly, these associations were observed only among premenopausal women. BMI (p=0.193) and waist circumference (p=0.072) showed no clear correlation with RCC frequency in postmenopausal participants.

This was confirmed in a multivariate logistic regression analysis, which showed that only premenopausal women who were overweight (odds ratio [OR], 1.67; 95 percent CI 1.01–2.76) and who were in the third (OR, 1.64; 1.12–2.39) or fourth (OR, 1.57; 1.07–2.30) quartiles of waist circumference were at significantly elevated risks of RCC.

No such associations were observed for the overall population (BMI 25 kg/m2: OR, 1.25; 0.95–1.65; quartile 3: OR, 1.64; 1.12–2.39; quartile 4: OR, 1.57; 1.07–2.30).

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Most Read Articles
Pearl Toh, 15 Jul 2019
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from the large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
15 Jul 2019
Fluticasone, swallowed from a multidose inhaler, and oral viscous budesonide slurry have comparable efficacies as initial treatment for eosinophilic oesophagitis, a recent study has found.
Yesterday
Health-related quality of life (HRQoL) among patients with kidney stone is worse in those who are young and female than those who are older and male, according to a recent study. Non-Caucasian patients also have a lower HRQoL.
Tristan Manalac, 2 days ago
In patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), admission Killip classification and creatinine and troponin levels are important cardiac mortality predictors, according to a recent Singapore study.