Oestrogen status modifies relationship between renal cell carcinoma risk and obesity in women
Oestrogen status appears to be an important modifying factor for the interaction between obesity and renal cell carcinoma (RCC) risk in women, a recent study has shown. Specifically, high body mass index (BMI) is associated with elevated RCC risk in pre- but not postmenopausal women.
The study included 445 female RCC patients (mean age 53.4±12.1 years) and 508 age-matched cancer-free controls (mean age 52.3±12.5 years). Immunohistochemistry was used to determine the expression levels of oestrogen receptor-β and insulin-like growth factor-1 receptor in RCC tissues.
Setting a BMI cutoff of 25 kg/m2, researchers showed that RCC was significantly common in patients who were overweight than in those who were not (67.27 percent vs 77.60 percent; p=0.029). A similar trend was obtained for quartiles of waist circumference: there were more RCC patients than controls in the highest quartile (21.82 percent vs 11.45 percent; p=0.001).
Interestingly, these associations were observed only among premenopausal women. BMI (p=0.193) and waist circumference (p=0.072) showed no clear correlation with RCC frequency in postmenopausal participants.
This was confirmed in a multivariate logistic regression analysis, which showed that only premenopausal women who were overweight (odds ratio [OR], 1.67; 95 percent CI 1.01–2.76) and who were in the third (OR, 1.64; 1.12–2.39) or fourth (OR, 1.57; 1.07–2.30) quartiles of waist circumference were at significantly elevated risks of RCC.
No such associations were observed for the overall population (BMI ≥25 kg/m2: OR, 1.25; 0.95–1.65; quartile 3: OR, 1.64; 1.12–2.39; quartile 4: OR, 1.57; 1.07–2.30).