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Oestrogen status modifies relationship between renal cell carcinoma risk and obesity in women

09 Sep 2018
The obesity epidemic hits Malaysia hard with cardiovascular disease occurring during younger ages.

Oestrogen status appears to be an important modifying factor for the interaction between obesity and renal cell carcinoma (RCC) risk in women, a recent study has shown. Specifically, high body mass index (BMI) is associated with elevated RCC risk in pre- but not postmenopausal women.

The study included 445 female RCC patients (mean age 53.4±12.1 years) and 508 age-matched cancer-free controls (mean age 52.3±12.5 years). Immunohistochemistry was used to determine the expression levels of oestrogen receptor-β and insulin-like growth factor-1 receptor in RCC tissues.

Setting a BMI cutoff of 25 kg/m2, researchers showed that RCC was significantly common in patients who were overweight than in those who were not (67.27 percent vs 77.60 percent; p=0.029). A similar trend was obtained for quartiles of waist circumference: there were more RCC patients than controls in the highest quartile (21.82 percent vs 11.45 percent; p=0.001).

Interestingly, these associations were observed only among premenopausal women. BMI (p=0.193) and waist circumference (p=0.072) showed no clear correlation with RCC frequency in postmenopausal participants.

This was confirmed in a multivariate logistic regression analysis, which showed that only premenopausal women who were overweight (odds ratio [OR], 1.67; 95 percent CI 1.01–2.76) and who were in the third (OR, 1.64; 1.12–2.39) or fourth (OR, 1.57; 1.07–2.30) quartiles of waist circumference were at significantly elevated risks of RCC.

No such associations were observed for the overall population (BMI 25 kg/m2: OR, 1.25; 0.95–1.65; quartile 3: OR, 1.64; 1.12–2.39; quartile 4: OR, 1.57; 1.07–2.30).

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Most Read Articles
Roshini Claire Anthony, 4 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 6 days ago
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
5 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.