Most Read Articles
Pearl Toh, 2 days ago
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6 days ago
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Pearl Toh, 07 Dec 2018
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Yesterday
Rates of major bleeding events are similar across cancer patients taking direct oral anticoagulants (DOAC), low-molecular-weight heparin (LMWH) or vitamin K antagonist (VKA), with gastrointestinal bleeding being the most frequent event, a recent study has shown. In addition, DOAC and LMWH recorded higher rates of venous thromboembolism than earlier studies.

Ocular surface involvement in psoriatic patients entails regular check-up, treatment

11 Mar 2018

In patients with psoriasis, ocular surface involvement implies the need for periodic ophthalmological examinations to diagnose the condition and allow proper treatment, which may help improve the patients’ quality of life, suggests a recent study.

Compared with healthy participants, those with psoriasis had a significant deterioration of the ocular surface tests as shown by tear film lipid layer alteration, tear film instability, corneal and conjunctival epithelial suffering, and mild squamous metaplasia at impression cytology.

There were no differences in ocular surface test results of the psoriatic group when patients were categorized based on the presence of arthritis. On the other hand, anti-inflammatory treatment with biological drugs showed a significant improvement in corneal stain and Meibomian gland dysfunction (MGD).

The investigators conducted a cross-sectional, comparative study to examine the presence of ocular discomfort symptoms and of ocular surface changes in 66 patients with psoriasis, who were subdivided according to the presence of arthritis and to the use of biological therapy.

All patients were clinically evaluated using the following tests: Ocular Surface Disease Index Questionnaire, Tearscope examination, meibometry, tear film breakup time, corneal and conjunctival fluorescein staining, Schirmer I test, corneal aesthesiometry, MGD assessment, and conjunctival impression cytology.

A total of 28 healthy individuals also underwent the same clinical tests. The investigators performed a statistical analysis of the results.

“Psoriasis is a skin disease with also systemic involvement; its impact on the eye is not well established and often clinically underestimated,” they noted.

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Most Read Articles
Pearl Toh, 2 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 07 Dec 2018
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.
Yesterday
Rates of major bleeding events are similar across cancer patients taking direct oral anticoagulants (DOAC), low-molecular-weight heparin (LMWH) or vitamin K antagonist (VKA), with gastrointestinal bleeding being the most frequent event, a recent study has shown. In addition, DOAC and LMWH recorded higher rates of venous thromboembolism than earlier studies.