Most Read Articles
22 Jul 2020
A picosecond alexandrite laser (PSAL) appears to be superior to Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota, as shown by its better clinical results and fewer adverse events, according to a study.
5 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
4 days ago
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 6 days ago

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

Ocular Surface Frailty Index predicts DED symptom onset after cataract surgery

13 Jul 2020

Noninvasive and low-tech procedures can be used to easily and quickly estimate the Ocular Surface Frailty Index (OSFI), which appears to predict the onset of postoperative dry eye disease (DED) symptoms, according to a recent study.

“This novel tool may allow cataract surgeons to perform a useful preoperative personalized risk assessment,” the authors said.

A total of 405 consecutive patients scheduled for phacoemulsification for age-related cataract were screened for this single-centre, observational, longitudinal study. Analysis was done on 284 eyes of 284 patients without preoperative DED symptoms who underwent uneventful cataract surgery.

The authors developed a tool to evaluate ocular surface frailty. Starting from a preliminary list of 19 potential items, they made the final OSFI—including 10 deficits in ocular surface health, factors potentially able to affect it, or both--through a stepwise approach.

The authors also calculated preoperative OSFI results for each enrolled patient and carried out diagnostic tests for DED at the screening visit and at 1 week, 1 month, and 3 months after surgery. Finally, the ability of OSFI to predict the presence of DED symptoms at 1 month or 3 months after surgery, or both, was evaluated.

OSFI scores among patients ranged from 0 to 0.666, with a median value of 0.200. Seventeen percent of the participants presented with postsurgical ocular surface symptoms.

A small group (19 percent of the asymptomatic patients) with frail ocular surfaces who showed a significantly higher risk of postsurgical DED symptoms onset (50.0 percent vs 9.6 percent; p<0.001, chi square test) was identified using an OSFI cutoff of 0.300.

On logistic regression analysis, OSFI results of 0.3—but not age, gender, or any preoperative sign—proved to be predictive of ocular surface symptom onset (odds ratio, 9.45, 95 percent CI, 4.74–18.82). Regression remained significant when performed on 200 bootstrapped samples.

Editor's Recommendations
Most Read Articles
22 Jul 2020
A picosecond alexandrite laser (PSAL) appears to be superior to Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota, as shown by its better clinical results and fewer adverse events, according to a study.
5 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
4 days ago
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 6 days ago

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.