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Octogenarians suffer from weaker vascular function

22 Sep 2020

Vascular function, such as endothelial and vascular smooth muscle functioning and arterial stiffness, are impaired in elderly adults, a recent Japan study has found.

Researchers enrolled 737 elderly adults, in whom flow-mediated dilation (FMD), nitroglycerine-induced vasodilation (NID), and brachial-ankle pulse wave velocity (baPWV) were all measured. All participants were instructed to fast the night before the vascular function tests and were asked to abstain from alcohol, smoking, caffeine, and antioxidant vitamins on the day itself.

The mean FMD, NID, and baPWV values in the study cohort were 2.7±2.5 percent, 11.3±5.6 percent, and 1,793±346 cm/s, respectively. Eighty-seven (11.8 percent) of the participants were in the oldest subgroup, aged ≥80 years.

In the oldest participants, FMD was significantly lower than in their counterparts aged 60–69 and 70–79 years (1.9±2.0 percent vs 2.9±2.6 percent and 2.7±2.6 percent; p=0.008 and p=0.03, respectively). The same was true for NID (8.6±5.1 percent vs 12.1±5.6 percent and 11.2±5.5 percent; p<0.001 for both). Both measures of vascular function were comparable between the two younger subgroups.

BaPWV, in contrast, was significantly higher in the oldest subgroup (1,978±452 vs 1,724±319 and 1,811±318 cm/s; p<0.001, respectively. The difference between the 70–79 and 60–69-year age groups was also statistically significant (p=0.003).

The present findings may help explain the high incidence rate of cardiovascular diseases in the elderly population in Japan.

“Further studies are needed to determine whether aggressive interventions with lifestyle modifications and pharmacological treatment decelerate the age-related deterioration of vascular functions,” the researchers said.

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Most Read Articles
Pearl Toh, 2 days ago
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
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Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.