Most Read Articles
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
13 Jun 2017
Both haemorrhagic and ischaemic stroke patients benefit similarly from a conventional therapy combined with robotic-assisted gait training (RAGT) intervention regimen, a new study shows.
30 Jun 2016
Perindopril can protect patients with paroxysmal atrial fibrillation (AF) from recurrence after radiofrequency catheter ablation, as stated in a study.
6 days ago
Enriching salt with both potassium and magnesium in the long term may provide additional benefits for stroke patient recovery from neurologic deficits, suggests a recent study involving Taiwanese patients.

Occupational PAH exposure ups risk of cardiovascular disease

13 Sep 2017
An Indian doctor has been awarded a SGD3 million grant to further study cardiovascular diseases.

Occupational exposure to polycyclic aromatic hydrocarbons (PAH) leads to higher levels of cardiovascular disease (CVD) risk markers, a recent study has shown.

Compared with the 152 controls (median age 43 years), chimney sweeps (n=151; median age 43 years) had significantly higher levels of exposure to the PAHs 1-hydroxypyrene (1-OH-PYR), 3-hydroxybenzo[a]pyrene (3-OH-BaP), 2-hydroxyphenanthrene (2-OH-PH) and 3-hydrxoybenzo[a]anthracene (3-OH-BaA; p<0.001 for all) even after controlling for age, smoking and BMI.

Specifically, the gravity-adjusted concentration of 1-OH-PYR was seven times higher in chimney sweeps than in controls. Values were four times higher for 2-OH-PH and three times higher for both 3-OH-BaP and 3-OH-BaA.

Levels of homocysteine (p≤0.001), high-density lipoprotein (HDL; p≤0.004) and cholesterol (p≤0.01) were all significantly elevated in chimney sweeps compared with healthy controls, according to the general linear models. Levels of triglycerides and low-density lipoproteins were higher but did not reach statistical significance.

In the final model, adjusted for all possible confounders such as smoking status and exposure to PAH from hobbies, only the association between 2-OH-PH and diastolic blood pressure remained statistically significant (β, 1.72; 95 percent CI, 0.66 to 2.78; p=0.002).

Chimney sweeps were recruited from 29 different companies across Sweden and usually performed soot sweeping, white sweeping and office work. Controls were employees from other companies and were not routinely expose to PAH.

Urine samples were collected from the participants and subjected to liquid chromatography coupled with mass spectrometry to measure PAH metabolite levels in urine. On the other hand, CVD markers were measured from serum samples.

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Most Read Articles
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
13 Jun 2017
Both haemorrhagic and ischaemic stroke patients benefit similarly from a conventional therapy combined with robotic-assisted gait training (RAGT) intervention regimen, a new study shows.
30 Jun 2016
Perindopril can protect patients with paroxysmal atrial fibrillation (AF) from recurrence after radiofrequency catheter ablation, as stated in a study.
6 days ago
Enriching salt with both potassium and magnesium in the long term may provide additional benefits for stroke patient recovery from neurologic deficits, suggests a recent study involving Taiwanese patients.