Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

Obeticholic acid cuts alkaline phosphatase levels in primary sclerosing cholangitis patients

23 Jun 2020

Obeticholic acid (OCA) reduces serum concentrations of alkaline phosphatase (ALP) in patients with primary sclerosing cholangitis, a new study has found.

Researchers enrolled 76 patients into the phase II, randomized, double-blind, placebo-controlled trial. The placebo and 1.5–3-mg OCA groups each had 25 patients, while the 5–10-mg OCA arm had 26 patients. The treatment phase lasted for 24 weeks and was followed by a 2-year, long-term safety extension (LTSE) period. Study endpoints were changes in ALP and safety.

In the intention-to-treat population, 5–10-mg of OCA triggered a significant drop in serum ALP by week 24 as compared to placebo (least square [LS] mean difference, –83.42±40.34 U/L; p=0.043). The same was also observed by week 12 (LS mean difference, –82.35±33.39 U/L; p=0.017).

This effect was first observed by week 6 and persisted until week 24; however, uptitrating doses to 10 mg did not intensify the effect of OCA on serum ALP.

Moreover, in patients who continued OCA treatment, this reduction also persisted during the LTSE period. Among those who switched into OCA from placebo, drops in ALP emerged starting at the 6-month visit.

Serum ALP at week 24 in the OCA 1.5–3-mg group was not statistically different than in placebo comparators (p=0.067).

During the double-blind phase, majority of the patients receiving active treatment reported at least one treatment-emergent adverse events (TEAEs). Most were mild or moderate in severity, but severe TEAEs were more common in both OCA groups than in the placebo arm. There were 10 cases of serious TEAEs, only two of which occurred in the control group.

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.