Most Read Articles
3 days ago
Monotherapy with tenofovir disoproxil fumarate increases virologic response for up to 240 weeks in pretreated patients with hepatitis B virus infection (HBV) who are resistant to entecavir and/or adefovir, a new study has found.
Elvira Manzano, 3 days ago
Long-term treatment with the interleukin-5 receptor alpha-directed cytolytic monoclonal antibody benralizumab led to long-term control of asthma, improvement in pulmonary function, and was safe in patients with severe eosinophilic asthma in the 2-year integrated analysis of the SIROCCO, CALIMA, and ZONDA pivotal studies plus the BORA extension study reported at ATS 2019.
Pearl Toh, 21 hours ago
Patients with rheumatoid arthritis (RA) who maintained their disease remission had a significantly reduced risk of clinical and subclinical atherosclerosis, according to the 3-year follow-up data of the GIRRCS* study presented at EULAR 2019.
2 days ago
Duodenal eosinophilia carries up to a sixfold increased risk of developing gastro-oesophageal reflux disease (GERD) over 10 years in individuals with functional dyspepsia (FD) and postprandial distress syndrome (PDS), a study has found.

Obesity ups risk of acute chronic liver failure in decompensated cirrhosis patients

26 Aug 2018
A higher than normal BMI is often a risk factor for many long-term health problems such as diabetes, hypertension, joint, heart and even liver problems.

In patients with decompensated cirrhosis, class III obesity increases the risk of acute on chronic liver failure (ACLF) development, a recent study has found.

Drawing from the United Network for Organ Sharing database, researchers identified 100,382 eligible participants, of whom 63,712 were nonobese (mean age 53.10±11.0 years; 62.9 percent male), 32,605 were class I–II obese (mean age 54.6±8.9 years; 63.8 percent male) and 4,065 were class III obese (mean age 52.6±9.1 years; 53.7 percent male).

At the time of liver transplantation, 7,630 patients had ACLF, of whom 4,688 were nonobese, 2,587 were class I–II obese and 355 were class III obese. Kaplan-Meier analysis revealed that those with class III obesity were significantly more likely to develop ACLF (p<0.001).

Multivariable Cox proportional hazards regression analysis further confirmed that class III obesity was a significant risk factor for ACLF (hazard ratio [HR], 1.24; 95 percent CI, 1.09–1.41; p<0.0001). The same was true for class I–II obesity (HR, 1.12; 1.05–1.19; p<0.001).

Other factors that significantly correlated with ACLF included older age, hepatitis C infection, ascites, alcoholic liver disease and hepatic encephalopathy.

Obesity was also associated with organ failure. While renal insufficiency was comparable between patient groups, renal failure was progressively more prevalent with increasing obesity class (p<0.001), and coagulation failure was most common in patients with class I–II obesity (51.3 percent). In contrast, liver failure as a component of ACLF was inversely correlated with obesity class.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Hepatology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago
Monotherapy with tenofovir disoproxil fumarate increases virologic response for up to 240 weeks in pretreated patients with hepatitis B virus infection (HBV) who are resistant to entecavir and/or adefovir, a new study has found.
Elvira Manzano, 3 days ago
Long-term treatment with the interleukin-5 receptor alpha-directed cytolytic monoclonal antibody benralizumab led to long-term control of asthma, improvement in pulmonary function, and was safe in patients with severe eosinophilic asthma in the 2-year integrated analysis of the SIROCCO, CALIMA, and ZONDA pivotal studies plus the BORA extension study reported at ATS 2019.
Pearl Toh, 21 hours ago
Patients with rheumatoid arthritis (RA) who maintained their disease remission had a significantly reduced risk of clinical and subclinical atherosclerosis, according to the 3-year follow-up data of the GIRRCS* study presented at EULAR 2019.
2 days ago
Duodenal eosinophilia carries up to a sixfold increased risk of developing gastro-oesophageal reflux disease (GERD) over 10 years in individuals with functional dyspepsia (FD) and postprandial distress syndrome (PDS), a study has found.