Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 5 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.

5 days ago
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Obesity ups liver-related mortality risk, exercise cuts it

24 May 2020
73% of workers aged above 40 were also found to be overweight or obese.

Obesity appears to be a strong risk factor for liver-related mortality, while exercise exerts a protective effect, a recent study has found.

Drawing from two nationwide population samples, researchers conducted a prospective cohort study on 77,238 women and 48,026 men with detailed and validated assessments of weekly physical activity, as expressed in metabolic equivalent task (MET)-hours. Other important factors were body mass index (BMI), waist circumference, diet, alcohol use and clinical comorbidities.

Multivariable Cox proportional hazards regression analysis found that each unit increase in cumulative average BMI correlated with a significant 5.1-percent jump in the risk of liver-related mortality (ptrend<0.0001).

When taken according to categories, BMI 25 to <30 kg/m2 (adjusted hazard ratio [HR], 1.40, 95 percent confidence interval [CI], 1.06–1.84), 30 to <35 kg/m2 (adjusted HR, 2.22, 95 percent CI, 1.56–3.16), and 35 kg/m2 (adjusted HR, 2.97, 95 percent CI, 1.84–4.79) were all significant risk factors for liver-related mortality than BMI 19 to <25 kg/m2.

Central adiposity had a similar effect. Each additional cm in WC correlated with a 5.6-percent increase in the risk of liver-related mortality (ptrend=0.003). Participants in the highest WC quartile were twice as likely as their lowest-quartile comparators to die of liver-related causes (adjusted HR, 2.09, 95 percent CI, 1.16–3.77).

In contrast, exercise appears to counteract this risk. Each additional 3 MET-hours per week of exercise led to a 3.5-percent drop in the risk of liver-related mortality. This protective effect intensified with increasing physical activity (ptrend<0.0001).

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Most Read Articles
06 Jul 2020
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, 5 days ago

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.

5 days ago
Maternal stress during pregnancy correlates with rapid weight gain of her infant, a recent study has found.