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Stephen Padilla, 5 days ago
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Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

Obesity ups liver-related mortality risk, exercise cuts it

24 May 2020
73% of workers aged above 40 were also found to be overweight or obese.

Obesity appears to be a strong risk factor for liver-related mortality, while exercise exerts a protective effect, a recent study has found.

Drawing from two nationwide population samples, researchers conducted a prospective cohort study on 77,238 women and 48,026 men with detailed and validated assessments of weekly physical activity, as expressed in metabolic equivalent task (MET)-hours. Other important factors were body mass index (BMI), waist circumference, diet, alcohol use and clinical comorbidities.

Multivariable Cox proportional hazards regression analysis found that each unit increase in cumulative average BMI correlated with a significant 5.1-percent jump in the risk of liver-related mortality (ptrend<0.0001).

When taken according to categories, BMI 25 to <30 kg/m2 (adjusted hazard ratio [HR], 1.40, 95 percent confidence interval [CI], 1.06–1.84), 30 to <35 kg/m2 (adjusted HR, 2.22, 95 percent CI, 1.56–3.16), and 35 kg/m2 (adjusted HR, 2.97, 95 percent CI, 1.84–4.79) were all significant risk factors for liver-related mortality than BMI 19 to <25 kg/m2.

Central adiposity had a similar effect. Each additional cm in WC correlated with a 5.6-percent increase in the risk of liver-related mortality (ptrend=0.003). Participants in the highest WC quartile were twice as likely as their lowest-quartile comparators to die of liver-related causes (adjusted HR, 2.09, 95 percent CI, 1.16–3.77).

In contrast, exercise appears to counteract this risk. Each additional 3 MET-hours per week of exercise led to a 3.5-percent drop in the risk of liver-related mortality. This protective effect intensified with increasing physical activity (ptrend<0.0001).

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.