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Stephen Padilla, 6 days ago
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Obesity protects against diabetic retinopathy in type 2 diabetes

12 Jun 2019

In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy (DR), a recent Korea study has shown.

Researchers enrolled 887 participants with type 2 diabetes into a nationwide survey. Seven-field fundus photographs were used to evaluate for the presence and severity of DR, while body fat was measured using dual-energy X-ray absorptiometry.

Only 185 participants (median age, 63 years; 42.2 percent male) were diagnosed with DR, while the rest were not (n=702; median age, 65 years; 50.3 percent male). Body mass index (BMI; p=0.001) and waist circumference (p=0.024) were significantly greater in those without DR. This trend was reflected for total body fat, but significance was not achieved (p=0.102).

Multivariate logistic regression analysis showed that BMI (adjusted odds ratio [OR], 0.80, 95 percent CI, 0.70–0.92; p=0.001) and waist circumference (adjusted OR, 0.86, 0.79–0.92; p<0.001) were significantly correlated with a lower likelihood of vision-threatening DR.

Obesity remained significantly predictive against DR risk when the Asian BMI cutoff values were used (adjusted OR, 0.65, 0.43–0.99; p-trend=0.029), as well as when participants were divided into tertiles of waist circumference (highest vs lowest: adjusted OR, 0.54, 0.32–0.91; p-trend=0.009).

Stratification of all analyses according to sex showed that total body fat remained significantly associated with DR risk only in females (adjusted OR, 0.93, 0.88–0.98; p=0.009). No such effect was observed in males or with the other obesity indices used.

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Most Read Articles
Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.