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Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
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Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
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Obesity not a reason for aggressive levofloxacin dosing for febrile neutropaenia prophylaxis

04 Oct 2020

Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.

“Levofloxacin given at a standard dose of 500 mg daily is recommended for antibacterial prophylaxis in patients receiving myelosuppressive chemotherapy,” the investigators said. “Obese patients have been shown to exhibit enhanced clearance of levofloxacin and may be at risk for prophylactic failure.”

To test this hypothesis, a single-centre, retrospective cohort study was conducted from June 2014 to May 2017, evaluating adult patients with estimated creatinine clearance ≥50 mL/min receiving their first cycle of a National Comprehensive Cancer Network defined intermediate-risk regimen.

The incidence of febrile neutropaenia was the primary outcome, while 30-day mortality and the correlation between estimated levofloxacin area under the concentration–time curve and rates of febrile neutropaenia were the secondary outcomes.

Twenty-six patients developed febrile neutropaenia: 12 (35.3 percent) obese and 14 (21.9 percent) nonobese (p=0.16). Of these, six (23.1 percent) required intensive care. No deaths were recorded within 30 days of a febrile neutropaenia event.

Obese and nonobese patients showed comparable estimated creatinine clearance (median, 97.5 vs 91.8 mL/min; p=0.39), as well as estimated levofloxacin area under the concentration–time curve (median, 85.6 vs 90.8 mg×h/L; p=0.39).

No significant associations were found between body weight-related variables—total body weight (median, 83.4 vs 80.6 kg; p=0.51), body mass index (mean 29.6 vs 26.8 kg/m2; p=0.35), or body surface area (1.98 vs 1.99 m2; p=0.68)—and febrile neutropaenia in this cohort of patients with similar renal function.

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Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
3 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.