Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Obesity not a reason for aggressive levofloxacin dosing for febrile neutropaenia prophylaxis

04 Oct 2020

Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.

“Levofloxacin given at a standard dose of 500 mg daily is recommended for antibacterial prophylaxis in patients receiving myelosuppressive chemotherapy,” the investigators said. “Obese patients have been shown to exhibit enhanced clearance of levofloxacin and may be at risk for prophylactic failure.”

To test this hypothesis, a single-centre, retrospective cohort study was conducted from June 2014 to May 2017, evaluating adult patients with estimated creatinine clearance ≥50 mL/min receiving their first cycle of a National Comprehensive Cancer Network defined intermediate-risk regimen.

The incidence of febrile neutropaenia was the primary outcome, while 30-day mortality and the correlation between estimated levofloxacin area under the concentration–time curve and rates of febrile neutropaenia were the secondary outcomes.

Twenty-six patients developed febrile neutropaenia: 12 (35.3 percent) obese and 14 (21.9 percent) nonobese (p=0.16). Of these, six (23.1 percent) required intensive care. No deaths were recorded within 30 days of a febrile neutropaenia event.

Obese and nonobese patients showed comparable estimated creatinine clearance (median, 97.5 vs 91.8 mL/min; p=0.39), as well as estimated levofloxacin area under the concentration–time curve (median, 85.6 vs 90.8 mg×h/L; p=0.39).

No significant associations were found between body weight-related variables—total body weight (median, 83.4 vs 80.6 kg; p=0.51), body mass index (mean 29.6 vs 26.8 kg/m2; p=0.35), or body surface area (1.98 vs 1.99 m2; p=0.68)—and febrile neutropaenia in this cohort of patients with similar renal function.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Oncology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.