Most Read Articles
Roshini Claire Anthony, 5 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 6 days ago
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
5 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.

Obesity negatively affects pulmonary vein isolation outcomes in drug-refractory AF

14 Jun 2018

Among patients with drug-refractory atrial fibrillation (AF), obesity is associated with lower pulmonary vein isolation (PVI) treatment success but not with increased adverse events, as reported in a study.

Researchers looked at 414 consecutive patients (mean age 56 years; 76 percent male) who underwent transcatheter PVI for AF between. PVI was considered successful if patients did not show atrial arrhythmia on Holter monitoring or ECG, with or without antiarrhythmic drugs during follow-up.

Of the patients, 311 (75 percent) had paroxysmal AF and 111 (27 percent) were obese (body mass index [BMI] ≥30 kg/m²). Mean duration of follow-up was 46 months.

Freedom from atrial arrhythmia and antiarrhythmic drugs occurred more frequently in nonobese vs obese patients (46 percent vs 30 percent; p=0.005). The same was true for the outcome of freedom from atrial arrhythmia but not antiarrhythmic drugs (68 percent vs 56 percent; p=0.036).

Minor and major adverse events (AEs), on the other hand, did not differ between patients with and without obesity (major AEs: 6 percent vs 3 percent, respectively; p=0.105; minor AEs: 5 percent vs 5 percent; p=0.512).

Sensitivity analyses revealed an association between BMI (as continuous variable) and PVI outcome (hazard ratio, 1.08; 95 percent CI, 1.02–1.14; p=0.012).

The present data highlight the importance of risk factor management, including weight loss, in patients with symptomatic AF before invasive treatment modalities are deployed, researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 6 days ago
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
5 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.