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Obesity linked to irregular periods, PCOS in type 1 diabetes

13 Aug 2020

Obesity is common among women with type 1 diabetes (T1D) and may mess with the menstrual cycle as well as contribute to an increased risk of polycystic ovary syndrome (PCOS), according to a study.

The analysis included 15,926 women (average age, 21 years), among whom 115 had T1D. Compared with nondiabetic controls, women with T1D had higher weight (median, 70 vs 64 kg) and body mass index (BMI; median, 25.5 vs 22.9 kg/m2), and greater prevalence of medical and psychiatric comorbidities.

Menstrual disorders were highly prevalent in both groups, with 47.8 percent of T1D patients and 40.3 percent of controls reporting menstrual irregularity at baseline. On the other hand, PCOS was significantly more prevalent in the T1D group (16.5 percent vs 5.5 percent).

Over 2 years, 3,220 controls and 31 women with T1D reported new menstrual irregularity. Incident cases of PCOS occurred in 899 and 11 women, respectively.

Log-binomial regression models showed that T1D conferred an increased risk of menstrual irregularity (risk ratio [RR], 1.22, 95 percent confidence interval [CI], 1.02–1.46) and PCOS (RR, 2.41, 95 percent CI, 1.70–3.42).

Moreover, obesity was associated with about a fourfold higher risk of PCOS compared with normal BMI (RR, 3.93, 95 percent CI, 3.51–4.42).

The findings indicate that a high BMI in women with T1D may have adverse reproductive implications, according to researchers. This underscores a need for monitoring and prevention of weight gain in young women with T1D, especially those with high BMI.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 6 days ago
For inflammatory bowel disease (IBD) patients, smoking cigarettes or just being exposed to secondhand smoke raises the risk of developing colorectal neoplasia, a study has found.
Jairia Dela Cruz, 2 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.