Most Read Articles
5 days ago
Among postmenopausal women, short sleep duration and depression contribute to increased fall accidents, as reported in a study.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Obesity detrimental in ankylosing spondylitis

08 Oct 2020

Obesity is tied to adverse outcomes in ankylosing spondylitis (AS), including inflammation, disease activity, physical mobility, radiographic damage, health index, liver function, and cardiovascular risk factors, a study suggests.

The researchers looked at 105 AS patients (median age, 48 years; 87.6 percent male), of which 11 (10.5 percent) had diabetes and 19 (18.1 percent) had hypertension.

Twenty-nine patients were obese (body mass index [BMI] 27), 36 were overweight (24 BMI <27), and 40 were of normal weight (18.5 BMI <24). Using other anthropometric measures, there were 67 obese patients according to waist circumference (WC; 80 cm in women and 90 cm in men) and 77 according to waist-to-height ratio (WHtR; 0.5). WHtR defined the highest number of obese patients with AS.

Obesity (BMI, WC, and WHtR) had an unfavourable influence on inflammation (C‐reactive protein [CRP]), physical mobility (Bath Ankylosing Spondylitis Metrology Index), radiographic damage (modified Stoke Ankylosing Spondylitis Spinal Score [m-SASSS]), health index (Assessment of SpondyloArthritis International Society Health Index), liver function, and blood pressure (p<0.05 for all).

Likewise, central obesity, as defined by WC and WHtR, correlated with disease activity (Ankylosing Spondylitis Disease Activity Score‐CRP; p=0.027 and p=0.025) and predicted longitudinal radiographic change (m‐SASSS; p=0.041 and p=0.045).

Central obesity was the best predictor of inflammation, disease activity, physical mobility, radiographic damage, and health index in AS. On the other hand, WHtR was the best for predicting m‐SASSS (area under the curve, 0.734; p<0.001).

Obesity conferred an increased risk of diabetes and hypertension.

The findings highlight the importance of preventing obesity in AS patients to improve their disease outcome, according to the researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
Among postmenopausal women, short sleep duration and depression contribute to increased fall accidents, as reported in a study.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.