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Obesity, sarcopenic obesity increase risk of knee osteoarthritis

11 Oct 2018

Obese and sarcopenic obese individuals are at high risk of knee osteoarthritis (OA), a study has found.

The study cohort comprised 1,667 individuals (mean age 62 years; 58 percent female; mean body mass index [BMI], 30 kg/m2) without radiographic knee OA at baseline participating in the Multicenter Osteoarthritis (MOST) study. A total of 1,653 who completed the 60-month follow-up were included in the final analysis.

Body composition (ie, fat and muscle mass) was measured using whole body dual energy x‐ray absorptiometry and categorized as obese, sarcopenic obese, sarcopenic and nonsarcopenic nonobese. These categories were then examined in relation to the risk of incident radiographic OA at 5 years using binomial regression adjusting for potential confounders.

There were 315 participants (19 percent) who developed radiographic knee OA over the study period. The risk of incident radiographic knee OA was significantly elevated in the obese group (women: risk ratio [RR], 2.29; 95 percent CI, 1.64–3.20; men: RR, 1.73; 1.08–2.78) and in the sarcopenic obese group only among women (RR, 1.91; 1.17–3.11) but not among men (RR, 1.74; 0.68–4.46).

On the other hand, the risk increase was not seen in the sarcopenia group (women: RR, 0.96; 0.62–1.49; men: RR, 0.66; 0.34–1.30).

The present data have implications for the management and prevention of knee OA, such that weight loss interventions should target both high fat and low muscle mass, researchers said.

The study was limited by the small sample size of sarcopenic obesity, the inclusion of Caucasians primarily and the observational nature of the study, among others.

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Most Read Articles
5 days ago
Living a sedentary lifestyle may increase the risk of cardiovascular diseases (CVD) even in people with healthy body mass index (BMI), reports a new study.
04 Feb 2019
The carbon-chain length of saturated fatty acids appears to be an important factor in determining its role in cardiovascular health, a recent study has found.
3 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
Jairia Dela Cruz, 04 Feb 2019
Treatment with secukinumab results in a higher rate of remission or low-disease activity at week 16 in patients with psoriatic arthritis as compared with placebo, according to a posthoc analysis of the FUTURE 2 study. This effect is sustained at 2 years and is evident in both tumour necrosis factor inhibitor-experienced and -naïve patients.