Obesity, sarcopenic obesity increase risk of knee osteoarthritis
Obese and sarcopenic obese individuals are at high risk of knee osteoarthritis (OA), a study has found.
The study cohort comprised 1,667 individuals (mean age 62 years; 58 percent female; mean body mass index [BMI], 30 kg/m2) without radiographic knee OA at baseline participating in the Multicenter Osteoarthritis (MOST) study. A total of 1,653 who completed the 60-month follow-up were included in the final analysis.
Body composition (ie, fat and muscle mass) was measured using whole body dual energy x‐ray absorptiometry and categorized as obese, sarcopenic obese, sarcopenic and nonsarcopenic nonobese. These categories were then examined in relation to the risk of incident radiographic OA at 5 years using binomial regression adjusting for potential confounders.
There were 315 participants (19 percent) who developed radiographic knee OA over the study period. The risk of incident radiographic knee OA was significantly elevated in the obese group (women: risk ratio [RR], 2.29; 95 percent CI, 1.64–3.20; men: RR, 1.73; 1.08–2.78) and in the sarcopenic obese group only among women (RR, 1.91; 1.17–3.11) but not among men (RR, 1.74; 0.68–4.46).
On the other hand, the risk increase was not seen in the sarcopenia group (women: RR, 0.96; 0.62–1.49; men: RR, 0.66; 0.34–1.30).
The present data have implications for the management and prevention of knee OA, such that weight loss interventions should target both high fat and low muscle mass, researchers said.
The study was limited by the small sample size of sarcopenic obesity, the inclusion of Caucasians primarily and the observational nature of the study, among others.