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Oat-derived beta-glucans help improve glucose control in teens with type 1 diabetes

12 Oct 2020

Consumption of beta-glucans from oat at 6 g daily is beneficial to teens with type 1 diabetes (T1D), helping achieve target blood sugar levels and reduce variability, a study reports.

Thirty adolescent T1D patients (mean age, 15.61 years) participated in a three-phase intervention. In the first phase, all participants followed a standard diet programme (composition: 45–55 percent carbohydrate, 15–20 percent protein, and 30–35 percent fat). In phases 2 and 3, the children consumed natural oat flakes containing 3 g/day and 6 g/day β-glucan, respectively, in addition to their standard diet. Each phase lasted a week, with a 2-week washout period between the interventions. Glucose levels were monitored using continuous glucose monitoring.

Mean time from diagnosis of diabetes was 6.8 years, and the mean HbA1c at baseline was 8.01 percent. Total insulin doses were 1.02 U/kg/day. Results showed that the maximal, mean, daytime and night, and minimal blood glucose levels were the lowest at phase 3 (p<0.05).

Premeal and postmeal blood glucose levels were likewise lowest at phase III for breakfast, lunch, and overall (p<0.05). Likewise, the lowest peak blood glucose levels occurred at phase III for breakfast, lunch, dinner, and overall (p<0.05).

Compared with phases 1 and 2, phase 3 recorded significantly lower levels of standard deviation, coefficient of variation, continuous overall net glycaemic action, and low blood glucose index levels (p<0.05 for each).

The findings suggest that the benefits of beta-glucan supplementation are only pronounced at 6 g/day dosing, while the impact on the glycaemic profile with the addition of 3-g daily beta-glucan is similar to that obtained with standard diet alone, according to the researchers.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
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