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Nutritional intervention not effective for preventing weight gain following kidney transplant

25 Aug 2018
Hospital Authority is set to introduce a pair exchange scheme for kidney transplants by the second half of 2018.

Intensive nutrition intervention programmes are not better than standard nutrition care in preventing weight gain in kidney transplant recipients 1 year after the operation, a recent study has found.

The single-blind randomized controlled trial included 36 adult kidney transplant recipients who were randomly assigned to receive the intensive intervention (n=18; mean age 49.2±14.6 years; 67 percent male) or standard nutrition care (n=18; mean age 48.3±13.9 years; 72 percent male). Weight at 6 months after the transplant was the primary outcome.

Mean body weight for the whole cohort increased from 78.0±13.7 kg at baseline to 79.6±13.0 kg at 6 months and 81.6±12.6 kg at 12 months, reflecting a significant 4.6-percent increase.

Analysis of covariance showed that mean weight at 6 months was statistically similar between both groups (intervention: 77±12.4 kg; control: 82.2±13.4 kg; adjusted mean difference, 0.4 kg; 95 percent CI, –2.2 to 3.0 kg; p=0.7).

In terms of secondary outcomes, no significant group-by-time interaction was observed for body mass index (p=0.354), waist circumference (p=0.484), hip circumference (p=0.608), total body fat (p=0.697), total body protein (p=0.861), total body potassium (p=0.175), resting energy expenditure (p=0.260) and other measures of anthropometry and body composition.

Both intervention groups likewise yielded similar outcomes in terms of grip strength (p=0.986), gait speed (p=0.304), sit-to-stand-to-sit test scores (p=0.167) and weekly physical activity (p=0.602), indicating comparable efficacies in terms of physical function.

In comparison, control participants showed significantly better general-health quality of life between 6 and 12 months (p=0.003), while total energy intake significantly decreased from baseline to 6 months in the intervention group (p=0.02).

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Most Read Articles
2 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

2 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
6 days ago
Empagliflozin treatment in patients with type 2 diabetes mellitus exerts beneficial effects on cardiovascular (CV) risk factors, including blood pressure and uric acid, according to a systematic review and meta-analysis.
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A 10 or 20 mg/kg daily dose of cannabidiol could almost halve the risk of seizures in children with Dravet syndrome, according to the phase III GWPCARE2* study presented at the American Academy of Neurology annual meeting (AAN 2019).