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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
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Nutraceuticals good for pain in knee, hip osteoarthritis

11 Dec 2020

Nutraceutical supplements may be helpful in improving pain intensity and physical function among patients with knee or hip osteoarthritis (OA), a recent Iran meta-analysis has found.

Drawing from the online databases of Medline, the Cochrane Library, Embase, Science Direct, ProQuest, Google Scholar, Scopus, and Web of Science, the researchers retrieved 42 eligible randomized controlled trials. Only those that used nutraceuticals as a primary or adjunctive intervention and enrolled adults with knee/hip OA were included. Persian-language databases SID, Magiran, Irandoc, and Iranmedex were also searched.

Overall, 4,160 patients and 33 supplements were included in the quantitative analysis. Twenty-eight of the included studies evaluated for total WOMAC* score over a mean follow-up of 17.4 weeks. Despite significant heterogeneity of evidence, patients on nutraceuticals showed significantly lower scores than their control counterparts (standardized mean difference [SMD], –0.23, 95 percent confidence interval [CI], –0.37 to –0.08; p=0.002).

Similarly, nutraceuticals also bested the control in terms of the pain (SMD, –0.37, 95 percent CI, –0.63 to –0.11; p=0.006) and stiffness (SMD, –0.48, 95 percent CI, –0.72 to –0.24; p<0.001) subscales of WOMAC, but not in the physical function domain (SMD, –0.25, 95 percent CI, –0.57 to –0.07; p=0.12).

Nutraceuticals likewise remained significantly better over control when pain was assessed using the visual analogue scale (VAS; SMD, –0.79, 95 percent CI, –1.06 to –0.52; p<0.001).

In terms of the quality of the included studies, the researchers detected no signals of publication bias the total WOMAC score and its pain and physical function subscale. On the other hand, bias was significant for the analyses on pain, as assessed by WOMAC or VAS.

*Western Ontario and McMaster Universities Arthritis index

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.