Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Nulliparous women with low cervical dilation more likely to need more anaesthetic interventions

01 Nov 2019

A single injection of spinal anaesthesia appears to be enough for multiparous women undergoing spontaneous labour with more advanced cervical dilation, a recent study has found.

Researchers retrospectively reviewed electronic medical records of 428 women (median age, 30 years) who received spinal analgesic blocks for labour. The primary outcome was the need for an additional anaesthetic intervention after the first administration of analgesia. Spinal, epidural and general anaesthesia, as well as intravenous sedation, were counted.

Sixty instances of required additional anaesthetic intervention were reported, resulting in an overall rate of 14.0 percent. The median time to additional administration was 115 minutes. These patients showed significantly longer time to delivery than their counterparts who did not require any additional anaesthetics (222 vs 48 minutes; p<0.001).

Multivariable logistic regression analysis found that higher age (odds ratio [OR] per 5 years, 1.41, 95 percent CI, 1.04–1.90; p=0.025), nulliparity (OR, 3.33, 1.72–6.43; p<0.001) and having low cervical dilation (OR per 1 cm, 0.87, 0.76–1.00; p=0.045) were all significant predictors for needing additional anaesthetic interventions.

Complications were rare (n=9; 2.1 percent) and were limited to postdural puncture headaches. Of those who developed the side effect, more than half (n=5; 55.6 percent) received successful epidural blood patches. There were no reports of neurologic or bleeding complications, and none of the participating women required treatment for pruritus.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.