Most Read Articles
Tristan Manalac, 6 days ago
Atopic dermatitis appears to impair sleep quality, but not sleep duration, in children, particularly in those with more severe diseases, according to a new study.
13 Mar 2019
Individuals following a diet low in or free of meat are at lower risk of diabetes, and this protective association is partly attributable to having a lower body mass index when compared with regular meat eaters, according to a study.
4 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
5 days ago
A recent study has shown that the short-term efficacy of tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) for the treatment of acute-on-chronic-liver failure (ACLF) due to reactivation of chronic hepatitis B (CHB).

NSAIDs neither prevent nor promote AMD incidence

01 Feb 2018

Nonsteroidal anti-inflammatory drugs (NSAIDs) appear to have little effect on the incidence of age-related macular degeneration (AMD), a study has found.

The study included 51,371 men from the California Men’s Health Study. Those with self-reported exposure to aspirin, ibuprofen, naproxen, valdecoxib, celecoxib and/or rofecoxib at least 3 days per week were considered NSAID users. NSAID use was categorized into former, new, longer-term and nonuse, as well as by type (any NSAIDs, aspirin and/or nonaspirin NSAID).

During an average follow-up of 7.4 years, a total of 292 (0.6 percent) cases of exudative AMD and 1,536 (3 percent) cases of nonexudative AMD were documented.

The risk of exudative AMD was found to be reduced among longer-term users of any NSAID (hazard ratio [HR], 0.69; 95 percent CI, 0.50–0.96; p=0.029). On the other hand, the risk of nonexudative AMD was lower among new users of any NSAID (HR, 0.79; 0.68–0.93; p=0.0039) and among new users of aspirin (HR, 0.82; 0.70–0.97; p=0.018). This particular trend did not persist in longer-term users.

Relationships observed between exudative or nonexudative AMD and the remaining categories of NSAID use were not significant.

Findings of the present study show that the overall impact of NSAIDs on AMD incidence is small, researchers said. “However, the lower risk of exudative AMD in longer-term NSAID users may point to a protective effect and deserves further study as a possible mechanism to modulate disease risk.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Tristan Manalac, 6 days ago
Atopic dermatitis appears to impair sleep quality, but not sleep duration, in children, particularly in those with more severe diseases, according to a new study.
13 Mar 2019
Individuals following a diet low in or free of meat are at lower risk of diabetes, and this protective association is partly attributable to having a lower body mass index when compared with regular meat eaters, according to a study.
4 days ago
Drinking coffee confers benefits for recurrence of hepatocellular carcinoma (HCC) and survival following orthotopic liver transplantation, a study has found.
5 days ago
A recent study has shown that the short-term efficacy of tenofovir disoproxil fumarate (TDF) is superior to entecavir (ETV) for the treatment of acute-on-chronic-liver failure (ACLF) due to reactivation of chronic hepatitis B (CHB).