Most Read Articles
5 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

3 days ago
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
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NSAIDs neither prevent nor promote AMD incidence

01 Feb 2018

Nonsteroidal anti-inflammatory drugs (NSAIDs) appear to have little effect on the incidence of age-related macular degeneration (AMD), a study has found.

The study included 51,371 men from the California Men’s Health Study. Those with self-reported exposure to aspirin, ibuprofen, naproxen, valdecoxib, celecoxib and/or rofecoxib at least 3 days per week were considered NSAID users. NSAID use was categorized into former, new, longer-term and nonuse, as well as by type (any NSAIDs, aspirin and/or nonaspirin NSAID).

During an average follow-up of 7.4 years, a total of 292 (0.6 percent) cases of exudative AMD and 1,536 (3 percent) cases of nonexudative AMD were documented.

The risk of exudative AMD was found to be reduced among longer-term users of any NSAID (hazard ratio [HR], 0.69; 95 percent CI, 0.50–0.96; p=0.029). On the other hand, the risk of nonexudative AMD was lower among new users of any NSAID (HR, 0.79; 0.68–0.93; p=0.0039) and among new users of aspirin (HR, 0.82; 0.70–0.97; p=0.018). This particular trend did not persist in longer-term users.

Relationships observed between exudative or nonexudative AMD and the remaining categories of NSAID use were not significant.

Findings of the present study show that the overall impact of NSAIDs on AMD incidence is small, researchers said. “However, the lower risk of exudative AMD in longer-term NSAID users may point to a protective effect and deserves further study as a possible mechanism to modulate disease risk.”

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Most Read Articles
5 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

3 days ago
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
5 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
3 days ago
The risk factors and outcomes associated with an increased risk of permanent pacing include atrial fibrillation (AF) ablation, multivalve surgery and New York Heart Association (NYHA) functional class III/IV, a recent study has found.